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Protein

Dihydroorotate dehydrogenase (quinone), mitochondrial

Gene

RCOM_0164820

Organism
Ricinus communis (Castor bean)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per subunit.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. dihydroorotate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

Flavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone), mitochondrialUniRule annotation (EC:1.3.5.2UniRule annotation)
Short name:
DHOdehaseUniRule annotation
Gene namesi
ORF Names:RCOM_0164820Imported
OrganismiRicinus communis (Castor bean)Imported
Taxonomic identifieri3988 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeAcalyphoideaeAcalypheaeRicinus
ProteomesiUP000008311 Componenti: Unassembled WGS sequence

Subcellular locationi

  1. Mitochondrion inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6519HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

InParanoidiB9SLA6.
KOiK00254.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00225. DHO_dh_type2.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9SLA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARASRRLL REFLYKKRTI VGGVRCMNSS APETLPKIPH FSRKGRLLTG
60 70 80 90 100
ATIGLVIAGG AYVSTVDEAT FCGWLFNATK LVNPFFALLD AEDAHTLAVS
110 120 130 140 150
AAARGWVPRE KRSDPSILGL EVWGRKFSNP LGLAAGFDKN AEAVEGLLGL
160 170 180 190 200
GFGSVEVGSV TPVPQEGNPK PRIFRLREEG AIINRCGFNS EGIVAVAKRL
210 220 230 240 250
GAQHGKRKLD ETSSTSSSPS DDVKHGGKAG PGILGVNLGK NKTSEDAAAD
260 270 280 290 300
YVQGVHTLSQ YADYLVINVS SPNTPGLRML QGRKQLKDLV KKVQAARDEM
310 320 330 340 350
QWGEEGPPPL LVKIAPDLSK EDLEDIAAVA LALRLDGLII TNTTISRPDL
360 370 380 390 400
VRKYPVAEES GGLSGKPLFD LSTDILKEMY ILTRGKIPLI GCGGISSGED
410 420 430 440 450
AYRKIRAGAT LVQIYTAFAY GGPALIPQIK TELAECLERD GFKSILEAVG

ADYR
Length:454
Mass (Da):48,653
Last modified:March 24, 2009 - v1
Checksum:iC92D550F7E89F1D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ974014 Genomic DNA. Translation: EEF35606.1.
RefSeqiXP_002526775.1. XM_002526729.1.

Genome annotation databases

GeneIDi8262675.
KEGGircu:RCOM_0164820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EQ974014 Genomic DNA. Translation: EEF35606.1.
RefSeqiXP_002526775.1. XM_002526729.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8262675.
KEGGircu:RCOM_0164820.

Phylogenomic databases

InParanoidiB9SLA6.
KOiK00254.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00225. DHO_dh_type2.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. HaleImported.

Entry informationi

Entry nameiB9SLA6_RICCO
AccessioniPrimary (citable) accession number: B9SLA6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: April 1, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.