SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B9PR34

- B9PR34_TOXGO

UniProt

B9PR34 - B9PR34_TOXGO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Bifunctional dihydrofolate reductase-thymidylate synthase
Gene
TGVEG_249180
Organism
Toxoplasma gondii
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei489 – 4891 By similarityUniRule annotation

GO - Molecular functioni

  1. dihydrofolate reductase activity Source: UniProtKB-EC
  2. thymidylate synthase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. dTMP biosynthetic process Source: InterPro
  2. glycine biosynthetic process Source: InterPro
  3. one-carbon metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseImported, OxidoreductaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Bifunctional dihydrofolate reductase-thymidylate synthaseImported (EC:1.5.1.3Imported, EC:2.1.1.45Imported)
Gene namesi
ORF Names:TGVEG_249180Imported
OrganismiToxoplasma gondii
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma
ProteomesiUP000002226: Partially assembled WGS sequence

Organism-specific databases

EuPathDBiToxoDB:TGME49_249180.

Structurei

3D structure databases

ProteinModelPortaliB9PR34.
SMRiB9PR34. Positions 322-610.

Family & Domainsi

Phylogenomic databases

OMAiLTCMIAQ.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
3.40.430.10. 2 hits.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR024072. DHFR-like_dom.
IPR012262. DHFR-TS.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
PF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF000389. DHFR-TS. 1 hit.
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF53597. SSF53597. 2 hits.
SSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9PR34-1 [UniParc]FASTAAdd to Basket

« Hide

MQKPVCLVVA MTPKRGIGIN NGLPWPHLTT DFKHFSRVTK TTPEEASRLN    50
GWLPRKFAKT GDSGLPSPSV GKRFNAVVMG RKTWESMPRK FRPLVDRLNI 100
VVSSSLKEED IAAEKPQAEG QQRVRVCASL PAALSLLEEE YKDSVDQIFV 150
VGGAGLYEAA LSLGVASHLY ITRVAREFPC DVFFPAFPGD DILSNKSTAA 200
QAAAPAESVF VPFCPELGRE KDNEATYRPI FISKTFSDNG VPYDFVVLEK 250
RRKTDDAATA EPSNAMSSLT STRETTPVHG LQAPSSAAAI APVLAWMDEE 300
DRKKREQKEL IRAVPHVHFR GHEEFQYLDL IADIINNGRT MDDRTGVGVI 350
SKFGCTMRYS LDQAFPLLTT KRVFWKGVLE ELLWFIRGDT NANHLSEKGV 400
KIWDKNVTRE FLDSRNLPHR EVGDIGPGYG FQWRHFGAAY KDMHTDYTGQ 450
GVDQLKNVIQ MLRTNPTDRR MLMTAWNPAA LDEMALPPCH LLCQFYVNDQ 500
KELSCIMYQR SCDVGLGVPF NIASYSLLTL MVAHVCNLKP KEFIHFMGNT 550
HVYTNHVEAL KEQLRREPRP FPIVNILNKE RIKEIDDFTA EDFEVVGYVP 600
HGRIQMEMAV 610
Length:610
Mass (Da):68,752
Last modified:March 24, 2009 - v1
Checksum:iCFAF564416D04A29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAYL02000077 Genomic DNA. Translation: ESS34444.1.

Genome annotation databases

EnsemblProtistsiTGME49_049180; TGME49_049180; TGME49_049180.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAYL02000077 Genomic DNA. Translation: ESS34444.1 .

3D structure databases

ProteinModelPortali B9PR34.
SMRi B9PR34. Positions 322-610.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi TGME49_049180 ; TGME49_049180 ; TGME49_049180 .

Organism-specific databases

EuPathDBi ToxoDB:TGME49_249180.

Phylogenomic databases

OMAi LTCMIAQ.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
3.40.430.10. 2 hits.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR024072. DHFR-like_dom.
IPR012262. DHFR-TS.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00186. DHFR_1. 1 hit.
PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF000389. DHFR-TS. 1 hit.
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF53597. SSF53597. 2 hits.
SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Annotation of Toxoplasma gondii VEG."
    Lorenzi H., Inman J., Amedeo P., Brunk B., Roos D., Caler E.
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 50861 / VEG.

Entry informationi

Entry nameiB9PR34_TOXGO
AccessioniPrimary (citable) accession number: B9PR34
Secondary accession number(s): B6KHC9, B9QD29
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: July 9, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi