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Protein

Biotin carboxylase 2, chloroplastic

Gene

POPTR_0018s14250g

Organism
Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.By similarity

Catalytic activityi

ATP + [biotin carboxyl-carrier protein]-biotin-N6-L-lysine + hydrogencarbonate- = ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N6-L-lysine.By similarity
ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.By similarity

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.
Proteins known to be involved in this subpathway in this organism are:
  1. Biotin carboxylase 2, chloroplastic (POPTR_0018s14250g), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta, chloroplastic (accD), Biotin carboxylase 1, chloroplastic (POPTRDRAFT_831870)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei181ATPBy similarity1
Binding sitei265ATPBy similarity1
Binding sitei300ATPBy similarity1
Metal bindingi340Magnesium or manganese 1PROSITE-ProRule annotation1
Metal bindingi353Magnesium or manganese 1PROSITE-ProRule annotation1
Metal bindingi353Magnesium or manganese 2PROSITE-ProRule annotation1
Metal bindingi355Magnesium or manganese 2PROSITE-ProRule annotation1
Active sitei357By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 274ATPPROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Biotin, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711

Names & Taxonomyi

Protein namesi
Recommended name:
Biotin carboxylase 2, chloroplastic (EC:6.3.4.14)
Alternative name(s):
Acetyl-CoA carboxylase subunit A 2 (EC:6.4.1.2)
Short name:
ACC
Gene namesi
ORF Names:POPTR_0018s14250g
OrganismiPopulus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa)
Taxonomic identifieri3694 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesSalicaceaeSaliceaePopulus
Proteomesi
  • UP000006729 Componentsi: Chromosome 18, Linkage group LGXVIII, Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 71ChloroplastSequence analysisAdd BLAST71
ChainiPRO_000039177472 – 526Biotin carboxylase 2, chloroplasticAdd BLAST455

Proteomic databases

PRIDEiB9N843

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein, biotin carboxylase and two subunits each of ACCase subunit alpha and ACCase plastid-coded subunit beta (accD).Curated

Protein-protein interaction databases

STRINGi3694.POPTR_0018s14250.1

Structurei

3D structure databases

SMRiB9N843
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 382ATP-graspPROSITE-ProRule annotationAdd BLAST198

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IU5C Eukaryota
COG0439 LUCA
HOGENOMiHOG000008988
InParanoidiB9N843
KOiK01961
OMAiFVEICSH
OrthoDBiEOG093607T8

Family and domain databases

InterProiView protein in InterPro
IPR004549 Acetyl_CoA_COase_biotin_COase
IPR011761 ATP-grasp
IPR005481 BC-like_N
IPR011764 Biotin_carboxylation_dom
IPR005482 Biotin_COase_C
IPR005479 CbamoylP_synth_lsu-like_ATP-bd
IPR016185 PreATP-grasp_dom_sf
IPR011054 Rudment_hybrid_motif
PfamiView protein in Pfam
PF02785 Biotin_carb_C, 1 hit
PF00289 Biotin_carb_N, 1 hit
PF02786 CPSase_L_D2, 1 hit
SMARTiView protein in SMART
SM00878 Biotin_carb_C, 1 hit
SUPFAMiSSF51246 SSF51246, 1 hit
SSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR00514 accC, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS50979 BC, 1 hit
PS00866 CPSASE_1, 1 hit
PS00867 CPSASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B9N843-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATLPVCKS VTSTPGLFMK RNSGIRNSQC SFMVGTKVNF PRQRTQATQA
60 70 80 90 100
NHCAKKNGGA LGVTCRAEKI LVANRGEIAV RVIRTAHELG IPCVAVYSTI
110 120 130 140 150
DKDALHVKLA DESVCIGEAP SNQSYLVIQN VLSAAISRGC TMLHPGYGFL
160 170 180 190 200
AENAVFVEMC REHGINFIGP NPDSIRVMGD KSTARETMKK ANVPTVPGSD
210 220 230 240 250
GLLQSTEEAV KLASEIGYPV MIKATAGGGG RGMRLAKEPD EFVKLLQQAK
260 270 280 290 300
SEAAAAFGND GVYLEKYVQN PRHIEFQVLA DKFGNVVHFG ERDCSIQRRN
310 320 330 340 350
QKLLEEAPSP ALTPELRKAM GDAAVAAAAS IGYIGVGTVE FLLDERGSFY
360 370 380 390 400
FMEMNTRIQV EHPVTEMISS VDLIEEQIRV AMGEKIQYKQ EDIVLRGHSI
410 420 430 440 450
ECRINAEDAF KGFRPGPGRI TAYLPSGGPF VRMDSHVYPD YVVPPSYDSL
460 470 480 490 500
LGKLIVWAPT REKAIERMKR ALDDTIITGV PTTIDYHKLI LDIEDFKNGN
510 520
VDTAFIPKHE QELAAPQQII LANSAS
Length:526
Mass (Da):57,497
Last modified:February 19, 2014 - v2
Checksum:iCAC6A56109E42892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM000354 Genomic DNA Translation: ERP49997.1
RefSeqiXP_006372200.1, XM_006372138.1

Genome annotation databases

EnsemblPlantsiPOPTR_0018s14250.1; POPTR_0018s14250.1; POPTR_0018s14250
GeneIDi18107844
GrameneiPOPTR_0018s14250.1; POPTR_0018s14250.1; POPTR_0018s14250
KEGGipop:POPTR_0018s14250g

Similar proteinsi

Entry informationi

Entry nameiACCC2_POPTR
AccessioniPrimary (citable) accession number: B9N843
Secondary accession number(s): U5FKU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 2, 2010
Last sequence update: February 19, 2014
Last modified: May 23, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways

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