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B9MS23 (PYRF_CALBD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase

EC=4.1.1.23
Alternative name(s):
OMP decarboxylase
Short name=OMPDCase
Short name=OMPdecase
Gene names
Name:pyrF
Ordered Locus Names:Athe_1377
OrganismCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum) [Complete proteome] [HAMAP]
Taxonomic identifier521460 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' UMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

'de novo' pyrimidine nucleobase biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionorotidine-5'-phosphate decarboxylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01215
PRO_1000164744

Sites

Active site1081Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
B9MS23 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: FD9616AB86EB63EC

FASTA30534,715
        10         20         30         40         50         60 
MLNFSDRLIE SIKKKNSVLI AGIDTSIENI PDYFIKRFYD KEKSEIDNLK TILFEYIRRI 

        70         80         90        100        110        120 
IDAVEENVVG VKFQAAFFEQ YSYHGFEVLH KLCEYTKNKK LVVIFDGKRN DISSSAKGYS 

       130        140        150        160        170        180 
NAYLGETPVF GKKMRFFEFD AITTNPYLGQ DGIKPFVEDC ERFKKGLFVL VKTSNPSSAD 

       190        200        210        220        230        240 
FQDLMVEDKY LFEVVAEKVY EWGKNCIGKE GYSDVGAVVG ATQPEAAKRI REILPNSFFL 

       250        260        270        280        290        300 
VPGIGVQGGK IEDLKYFVDS NNMGIIVNSS RDIIYAYKNY VHSDFEKSSY LASKNIKESI 


NAAIS 

« Hide

References

[1]"Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1888 / DSM 6725 / Z-1320.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001393 Genomic DNA. Translation: ACM60477.1.
RefSeqYP_002573250.1. NC_012034.1.

3D structure databases

ProteinModelPortalB9MS23.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING521460.Athe_1377.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM60477; ACM60477; Athe_1377.
GeneID7409120.
KEGGate:Athe_1377.
PATRIC20899870. VBIAnaThe135187_1448.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000245747.
KOK01591.
OrthoDBEOG6DZF33.

Enzyme and pathway databases

BioCycCBES521460:GH8H-1396-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01215. OMPdecase_type2.
InterProIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR02127. pyrF_sub2. 1 hit.
ProtoNetSearch...

Entry information

Entry namePYRF_CALBD
AccessionPrimary (citable) accession number: B9MS23
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways