B9MRJ6 (B9MRJ6_ANATD) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Porphobilinogen synthase EMBL ACM60300.1
EC=4.2.1.24 EMBL ACM60300.1

Gene names

Ordered Locus Names:

Athe_1200

Organism

Anaerocellum thermophilum (strain DSM 6725 / Z-1320) [Complete proteome] [HAMAP]

Taxonomic identifier

521460 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase EMBL ACM60300.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tetrapyrrole biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	193	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	246	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	118	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	120	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	128	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	231	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	203	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	215	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	272	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	311	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	B9MRJ6 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 06F74D9C44F939D8	FASTA	325	36,376
	10 20 30 40 50 60 MEFKRLRRLR QTKALRELFY ETRLYSKEFV FPLFIDDGKN VFERMPQLDG IVKVSVDRLQ 70 80 90 100 110 120 EALDEIKKAD IGGVILFGVT SQKDEMGSYA TKDDGAVQHA IRKIKEYSED ILVFADVCLC 130 140 150 160 170 180 EYTSHGHCGI LKGDKIDNDK TIEVLSEIAL SYAKAGADII CPSDMMDGRV AAIRKKLDSH 190 200 210 220 230 240 GFVYTPIIPY SAKFASSLYA PFRDVANSRP AFGDRKSYQM PYQNKREALR EIEADILEGA 250 260 270 280 290 300 DAVIIKPALT SLDVISAAKE KFNIPIIAYN VSGEYAMVKS AGKLGFLNEE EVIIEILTAI 310 320 KRAGADAIIT YHALEAARIL NRKEL

References

[1]

"Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001393 Genomic DNA. Translation: ACM60300.1.
RefSeq	YP_002573073.1. NC_012034.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B9MRJ6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7409674.
GenomeReviews	Gene locus Athe_1200 in contig CP001393_GR.
KEGG	ate:Athe_1200.
PATRIC	20899512. VBIAnaThe135187_1269.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TEAYNEN.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B9MRJ6_ANATD

Accession

Primary (citable) accession number: B9MRJ6

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)