murB

Functionⁱ

Cell wall formation.UniRule annotation

Catalytic activityⁱ

UDP-N-acetyl-alpha-D-muramate + NADP⁺ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactorⁱ

FADUniRule annotation

Pathwayⁱ: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	171	UniRule annotation	1
Active siteⁱ	223	Proton donorUniRule annotation	1
Active siteⁱ	293	UniRule annotation	1

GO - Molecular functionⁱ

flavin adenine dinucleotide binding Source: InterPro
UDP-N-acetylmuramate dehydrogenase activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
cell wall organization Source: UniProtKB-KW
peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
regulation of cell shape Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
Ligand	FAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayⁱ	UPA00219.

UniPathwayⁱ

UPA00219.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation) Alternative name(s): UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesⁱ	Name:murBUniRule annotation Ordered Locus Names:Athe_0319
Organismⁱ	Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Taxonomic identifierⁱ	521460 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor › Caldicellulosiruptor bescii
Proteomesⁱ	UP000007723 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00037

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000191394	1 – 314	UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST		314

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	521460.Athe_0319.

STRINGⁱ

521460.Athe_0319.

Structureⁱ

3D structure databases

SMRⁱ	B9MN03.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 192	FAD-binding PCMH-typeUniRule annotationAdd BLAST		166

Sequence similaritiesⁱ

Belongs to the MurB family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105D4A. Bacteria. COG0812. LUCA.
HOGENOMⁱ	HOG000284355.
KEGG Orthology (KO) More...KOⁱ	K00075.
OMAⁱ	IGNAGSF.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0270.

Family and domain databases

Gene3Dⁱ	3.30.43.10. 1 hit. 3.30.465.10. 1 hit. 3.90.78.10. 1 hit.
HAMAPⁱ	MF_00037. MurB. 1 hit.
InterProⁱ	View protein in InterPro IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR003170. MurB. IPR011601. MurB_C. IPR006094. Oxid_FAD_bind_N.
PANTHERⁱ	PTHR21071. PTHR21071. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01565. FAD_binding_4. 1 hit. PF02873. MurB_C. 1 hit.
SUPFAMⁱ	SSF56176. SSF56176. 1 hit. SSF56194. SSF56194. 1 hit.
TIGRFAMsⁱ	TIGR00179. murB. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51387. FAD_PCMH. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B9MN03-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEFEMYLKNS GIEFLKDHPL KEFTTFKIGG KARYIVFPKS TKQLIEILTL 
        60         70         80         90        100
AKDEAINYIV VGNCSNVLVS DKGYNGAIIT TVKIDSFKID GNLIEAECGA 
       110        120        130        140        150
MLSHVARKAC EAGLKGLEFA VGIPGTVGGA VYMNAGAYDG EIKDVFERAE 
       160        170        180        190        200
VLDENLNPVE LGRADMRFSY RNSRLKEEKM VLLRAVFCLK FADREDISPL 
       210        220        230        240        250
QKANEFSKRR REKQPLSYPS AGSVFKRPPN NFAGKLIEDA GLKGYRIGGA 
       260        270        280        290        300
CISEKHAGFI INLGDAKAED VRKLIYLAQK SVYEKFGILL EPEIQFIGEF 
       310 
ETPLFVPVDG QNRR

Length:314

Mass (Da):34,982

Last modified:March 24, 2009 - v1

Checksum:ⁱD006402EF2DCEB01

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001393 Genomic DNA. Translation: ACM59459.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_015906924.1. NC_012034.1.

Genome annotation databases

EnsemblBacteriaⁱ	ACM59459; ACM59459; Athe_0319.
GeneIDⁱ	31771686.
KEGGⁱ	ate:Athe_0319.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001393 Genomic DNA. Translation: ACM59459.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_015906924.1. NC_012034.1.

3D structure databases

SMRⁱ	B9MN03.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	521460.Athe_0319.

STRINGⁱ

521460.Athe_0319.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ACM59459; ACM59459; Athe_0319.
GeneIDⁱ	31771686.
KEGGⁱ	ate:Athe_0319.

Phylogenomic databases

eggNOGⁱ	ENOG4105D4A. Bacteria. COG0812. LUCA.
HOGENOMⁱ	HOG000284355.
KEGG Orthology (KO) More...KOⁱ	K00075.
OMAⁱ	IGNAGSF.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0270.

Enzyme and pathway databases

UniPathwayⁱ	UPA00219.

UniPathwayⁱ

UPA00219.

Family and domain databases

Gene3Dⁱ	3.30.43.10. 1 hit. 3.30.465.10. 1 hit. 3.90.78.10. 1 hit.
HAMAPⁱ	MF_00037. MurB. 1 hit.
InterProⁱ	View protein in InterPro IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR003170. MurB. IPR011601. MurB_C. IPR006094. Oxid_FAD_bind_N.
PANTHERⁱ	PTHR21071. PTHR21071. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01565. FAD_binding_4. 1 hit. PF02873. MurB_C. 1 hit.
SUPFAMⁱ	SSF56176. SSF56176. 1 hit. SSF56194. SSF56194. 1 hit.
TIGRFAMsⁱ	TIGR00179. murB. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51387. FAD_PCMH. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MURB_CALBD
Accessionⁱ	B9MN03Primary (citable) accession number: B9MN03
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
	Last sequence update:	March 24, 2009
	Last modified:	June 7, 2017
	This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B9MN03 (MURB_CALBD)

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UDP-N-acetylenolpyruvoylglucosamine reductase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidoglycan biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: peptidoglycan biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ