UniProtKB - B9MN03 (MURB_CALBD)
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Protein
UDP-N-acetylenolpyruvoylglucosamine reductase
Gene
murB
Organism
Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Status
Functioni
Cell wall formation.UniRule annotation
Catalytic activityi
UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation
Cofactori
FADUniRule annotation
: peptidoglycan biosynthesis Pathwayi
This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 171 | UniRule annotation | 1 | |
Active sitei | 223 | Proton donorUniRule annotation | 1 | |
Active sitei | 293 | UniRule annotation | 1 |
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: InterPro
- UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- cell wall organization Source: UniProtKB-KW
- peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis |
Ligand | FAD, Flavoprotein, NADP |
Enzyme and pathway databases
BioCyci | CBES521460:G1GUU-317-MONOMER. |
UniPathwayi | UPA00219. |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)Alternative name(s): UDP-N-acetylmuramate dehydrogenaseUniRule annotation |
Gene namesi | Name:murBUniRule annotation Ordered Locus Names:Athe_0319 |
Organismi | Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum) |
Taxonomic identifieri | 521460 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000191394 | 1 – 314 | UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST | 314 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 192 | FAD-binding PCMH-typeUniRule annotationAdd BLAST | 166 |
Sequence similaritiesi
Belongs to the MurB family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105D4A. Bacteria. COG0812. LUCA. |
HOGENOMi | HOG000284355. |
KOi | K00075. |
OMAi | IGNAGSF. |
OrthoDBi | POG091H0270. |
Family and domain databases
Gene3Di | 3.30.43.10. 1 hit. 3.90.78.10. 1 hit. |
HAMAPi | MF_00037. MurB. 1 hit. |
InterProi | View protein in InterPro IPR016166. FAD-bd_2. IPR036318. FAD-bd_2-like_sf. IPR016167. FAD-bd_2_sub1. IPR003170. MurB. IPR011601. MurB_C. IPR036635. MurB_C_sf. IPR006094. Oxid_FAD_bind_N. |
PANTHERi | PTHR21071. PTHR21071. 1 hit. |
Pfami | View protein in Pfam PF01565. FAD_binding_4. 1 hit. PF02873. MurB_C. 1 hit. |
SUPFAMi | SSF56176. SSF56176. 1 hit. SSF56194. SSF56194. 1 hit. |
TIGRFAMsi | TIGR00179. murB. 1 hit. |
PROSITEi | View protein in PROSITE PS51387. FAD_PCMH. 1 hit. |
i Sequence
Sequence statusi: Complete.
B9MN03-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFEMYLKNS GIEFLKDHPL KEFTTFKIGG KARYIVFPKS TKQLIEILTL
60 70 80 90 100
AKDEAINYIV VGNCSNVLVS DKGYNGAIIT TVKIDSFKID GNLIEAECGA
110 120 130 140 150
MLSHVARKAC EAGLKGLEFA VGIPGTVGGA VYMNAGAYDG EIKDVFERAE
160 170 180 190 200
VLDENLNPVE LGRADMRFSY RNSRLKEEKM VLLRAVFCLK FADREDISPL
210 220 230 240 250
QKANEFSKRR REKQPLSYPS AGSVFKRPPN NFAGKLIEDA GLKGYRIGGA
260 270 280 290 300
CISEKHAGFI INLGDAKAED VRKLIYLAQK SVYEKFGILL EPEIQFIGEF
310
ETPLFVPVDG QNRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP001393 Genomic DNA. Translation: ACM59459.1. |
RefSeqi | WP_015906924.1. NC_012034.1. |
Genome annotation databases
EnsemblBacteriai | ACM59459; ACM59459; Athe_0319. |
GeneIDi | 31771686. |
KEGGi | ate:Athe_0319. |
Similar proteinsi
Entry informationi
Entry namei | MURB_CALBD | |
Accessioni | B9MN03Primary (citable) accession number: B9MN03 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 28, 2009 |
Last sequence update: | March 24, 2009 | |
Last modified: | March 28, 2018 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |