murB

Functionⁱ

Cell wall formation.UniRule annotation

Catalytic activityⁱ

UDP-N-acetyl-alpha-D-muramate + NADP⁺ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactorⁱ

FADUniRule annotation

Pathwayⁱ: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	171	UniRule annotation	1
Active siteⁱ	223	Proton donorUniRule annotation	1
Active siteⁱ	293	UniRule annotation	1

GO - Molecular functionⁱ

flavin adenine dinucleotide binding Source: InterPro
UDP-N-acetylmuramate dehydrogenase activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW
cell wall organization Source: UniProtKB-KW
peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
regulation of cell shape Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
Ligand	FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCycⁱ	CBES521460:G1GUU-317-MONOMER.
UniPathwayⁱ	UPA00219.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation) Alternative name(s): UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesⁱ	Name:murBUniRule annotation Ordered Locus Names:Athe_0319
Organismⁱ	Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Taxonomic identifierⁱ	521460 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Clostridia › Thermoanaerobacterales › Thermoanaerobacterales Family III. Incertae Sedis › Caldicellulosiruptor › Caldicellulosiruptor bescii
Proteomesⁱ	UP000007723 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00037

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000191394	1 – 314	UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST		314

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	521460.Athe_0319.

STRINGⁱ

521460.Athe_0319.

Structureⁱ

3D structure databases

SMRⁱ	B9MN03.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	27 – 192	FAD-binding PCMH-typeUniRule annotationAdd BLAST		166

Sequence similaritiesⁱ

Belongs to the MurB family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105D4A. Bacteria. COG0812. LUCA.
HOGENOMⁱ	HOG000284355.
KEGG Orthology (KO) More...KOⁱ	K00075.
OMAⁱ	IGNAGSF.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0270.

Family and domain databases

Gene3Dⁱ	3.30.43.10. 1 hit. 3.90.78.10. 1 hit.
HAMAPⁱ	MF_00037. MurB. 1 hit.
InterProⁱ	View protein in InterPro IPR016166. FAD-bd_2. IPR036318. FAD-bd_2-like_sf. IPR016167. FAD-bd_2_sub1. IPR003170. MurB. IPR011601. MurB_C. IPR036635. MurB_C_sf. IPR006094. Oxid_FAD_bind_N.
PANTHERⁱ	PTHR21071. PTHR21071. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01565. FAD_binding_4. 1 hit. PF02873. MurB_C. 1 hit.
SUPFAMⁱ	SSF56176. SSF56176. 1 hit. SSF56194. SSF56194. 1 hit.
TIGRFAMsⁱ	TIGR00179. murB. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51387. FAD_PCMH. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B9MN03-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEFEMYLKNS GIEFLKDHPL KEFTTFKIGG KARYIVFPKS TKQLIEILTL 
        60         70         80         90        100
AKDEAINYIV VGNCSNVLVS DKGYNGAIIT TVKIDSFKID GNLIEAECGA 
       110        120        130        140        150
MLSHVARKAC EAGLKGLEFA VGIPGTVGGA VYMNAGAYDG EIKDVFERAE 
       160        170        180        190        200
VLDENLNPVE LGRADMRFSY RNSRLKEEKM VLLRAVFCLK FADREDISPL 
       210        220        230        240        250
QKANEFSKRR REKQPLSYPS AGSVFKRPPN NFAGKLIEDA GLKGYRIGGA 
       260        270        280        290        300
CISEKHAGFI INLGDAKAED VRKLIYLAQK SVYEKFGILL EPEIQFIGEF 
       310 
ETPLFVPVDG QNRR

Length:314

Mass (Da):34,982

Last modified:March 24, 2009 - v1

Checksum:ⁱD006402EF2DCEB01

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001393 Genomic DNA. Translation: ACM59459.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_015906924.1. NC_012034.1.

Genome annotation databases

EnsemblBacteriaⁱ	ACM59459; ACM59459; Athe_0319.
GeneIDⁱ	31771686.
KEGGⁱ	ate:Athe_0319.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B9MN03	A0A2G6V7W1	Caldicellulosiruptor bescii (Anaerocellum thermophilum)	314	UniRef100_B9MN03	Cluster: UDP-N-acetylenolpyruvoylglucosamine reductase	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B9MN03	A0A2G6V7W1 E4SHA1 E4Q8N4 UPI00031B97BA	Caldicellulosiruptor bescii (Anaerocellum thermophilum) Caldicellulosiruptor kronotskyensis (strain DSM 18902 / VKM B-2412 / 2002) Caldicellulosiruptor hydrothermalis (strain DSM 18901 / VKM B-2411 / 108) Caldicellulosiruptor hydrothermalis	314	UniRef90_B9MN03	Cluster: UDP-N-acetylenolpyruvoylglucosamine reductase	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B9MN03	A4XIM9 UPI0003A6039C UPI0005EB7777 E4S7J8 E4Q2R3 UPI0002D82D78 G2PVN5 UPI0003FAA06F D9THZ9 UPI0005EACF9F +6	Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331) Caldicellulosiruptor sp. F32 Thermoanaerobacter cellulolyticus Caldicellulosiruptor kristjanssonii (strain ATCC 700853 / DSM 12137 / I77R1B) Caldicellulosiruptor owensensis (strain ATCC 700167 / DSM 13100 / OL) Caldicellulosiruptor owensensis Caldicellulosiruptor lactoaceticus 6A Caldicellulosiruptor acetigenus Caldicellulosiruptor obsidiansis (strain ATCC BAA-2073 / strain OB47) Caldicellulosiruptor sp. Wai35.B1 And more	310	UniRef50_A4XIM9	Cluster: UDP-N-acetylenolpyruvoylglucosamine reductase	17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP001393 Genomic DNA. Translation: ACM59459.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_015906924.1. NC_012034.1.

3D structure databases

SMRⁱ	B9MN03.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	521460.Athe_0319.

STRINGⁱ

521460.Athe_0319.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ACM59459; ACM59459; Athe_0319.
GeneIDⁱ	31771686.
KEGGⁱ	ate:Athe_0319.

Phylogenomic databases

eggNOGⁱ	ENOG4105D4A. Bacteria. COG0812. LUCA.
HOGENOMⁱ	HOG000284355.
KEGG Orthology (KO) More...KOⁱ	K00075.
OMAⁱ	IGNAGSF.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0270.

Enzyme and pathway databases

UniPathwayⁱ	UPA00219.
BioCycⁱ	CBES521460:G1GUU-317-MONOMER.

Family and domain databases

Gene3Dⁱ	3.30.43.10. 1 hit. 3.90.78.10. 1 hit.
HAMAPⁱ	MF_00037. MurB. 1 hit.
InterProⁱ	View protein in InterPro IPR016166. FAD-bd_2. IPR036318. FAD-bd_2-like_sf. IPR016167. FAD-bd_2_sub1. IPR003170. MurB. IPR011601. MurB_C. IPR036635. MurB_C_sf. IPR006094. Oxid_FAD_bind_N.
PANTHERⁱ	PTHR21071. PTHR21071. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01565. FAD_binding_4. 1 hit. PF02873. MurB_C. 1 hit.
SUPFAMⁱ	SSF56176. SSF56176. 1 hit. SSF56194. SSF56194. 1 hit.
TIGRFAMsⁱ	TIGR00179. murB. 1 hit.
PROSITEⁱ	View protein in PROSITE PS51387. FAD_PCMH. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MURB_CALBD
Accessionⁱ	B9MN03Primary (citable) accession number: B9MN03
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
	Last sequence update:	March 24, 2009
	Last modified:	March 28, 2018
	This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B9MN03 (MURB_CALBD)

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UDP-N-acetylenolpyruvoylglucosamine reductase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidoglycan biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: peptidoglycan biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ