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B9MM59

- FTHS_CALBD

UniProt

B9MM59 - FTHS_CALBD

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 708ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBES521460:GH8H-2254-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Athe_2208
OrganismiCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Taxonomic identifieri521460 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
ProteomesiUP000007723: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Formate--tetrahydrofolate ligasePRO_1000185243Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi521460.Athe_2208.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

B9MM59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSISKVEEV LEPISKIAEK IGLDEDEIEL YGKYKAKISL DILKKKAQLQ
60 70 80 90 100
EGKVILVTSI NPTPFGEGKT TTAIGLSMAI NRLGFKSIVT LREPSLGPFL
110 120 130 140 150
GLKGGATGGG ASQILPSIDI NLHFTGDIHA VTSANNLLCA AVDNHIYHGN
160 170 180 190 200
RLGINPKSIT IKRAMDMNDR SLRHIIVGLS NDQKGAIRED GFVISVASEV
210 220 230 240 250
MAVLCLSMSY DDLKEKLGNI LVGFTYDKKP VYAKDLNVHG SMALLLKDAL
260 270 280 290 300
KPNLVQTSEN TAAIVHGGPF ANIAHGTNSI VATKIAQKLS EYVVVEAGFG
310 320 330 340 350
SDLGAEKFIN IVARKSGIYP QAAVLVVTVK ALKHHAKIEE NSGLQSGVNS
360 370 380 390 400
IQQGLENLEK HIENLKVMGL ETVVALNKFP DDKDEEIELI RSFCEEMGVE
410 420 430 440 450
FSVSSAYTHG SEGVLELAEK VIRLSDKRKR INFVYQDSDF IEEKIKKVAT
460 470 480 490 500
IIYGAKDVKF SKAALSKLEL IKNLKVEHFP ICMSKTQYSL SDDPKLLGKP
510 520 530 540 550
KDFILNVTDI EIKNGAGFIV VMCGDIIAMP GLGKDFAALH LDIDSSGNPI

FK
Length:552
Mass (Da):59,985
Last modified:March 24, 2009 - v1
Checksum:i92CED9E624C09A5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001393 Genomic DNA. Translation: ACM61282.1.
RefSeqiYP_002574055.1. NC_012034.1.

Genome annotation databases

EnsemblBacteriaiACM61282; ACM61282; Athe_2208.
GeneIDi7408404.
KEGGiate:Athe_2208.
PATRICi20901682. VBIAnaThe135187_2326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001393 Genomic DNA. Translation: ACM61282.1 .
RefSeqi YP_002574055.1. NC_012034.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 521460.Athe_2208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM61282 ; ACM61282 ; Athe_2208 .
GeneIDi 7408404.
KEGGi ate:Athe_2208.
PATRICi 20901682. VBIAnaThe135187_2326.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci CBES521460:GH8H-2254-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725."
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1888 / DSM 6725 / Z-1320.

Entry informationi

Entry nameiFTHS_CALBD
AccessioniPrimary (citable) accession number: B9MM59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3