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B9MM59

- FTHS_CALBD

UniProt

B9MM59 - FTHS_CALBD

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi63 – 708ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCBES521460:GH8H-2254-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Athe_2208
    OrganismiCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
    Taxonomic identifieri521460 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000007723: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 552552Formate--tetrahydrofolate ligasePRO_1000185243Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi521460.Athe_2208.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9MM59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKSISKVEEV LEPISKIAEK IGLDEDEIEL YGKYKAKISL DILKKKAQLQ    50
    EGKVILVTSI NPTPFGEGKT TTAIGLSMAI NRLGFKSIVT LREPSLGPFL 100
    GLKGGATGGG ASQILPSIDI NLHFTGDIHA VTSANNLLCA AVDNHIYHGN 150
    RLGINPKSIT IKRAMDMNDR SLRHIIVGLS NDQKGAIRED GFVISVASEV 200
    MAVLCLSMSY DDLKEKLGNI LVGFTYDKKP VYAKDLNVHG SMALLLKDAL 250
    KPNLVQTSEN TAAIVHGGPF ANIAHGTNSI VATKIAQKLS EYVVVEAGFG 300
    SDLGAEKFIN IVARKSGIYP QAAVLVVTVK ALKHHAKIEE NSGLQSGVNS 350
    IQQGLENLEK HIENLKVMGL ETVVALNKFP DDKDEEIELI RSFCEEMGVE 400
    FSVSSAYTHG SEGVLELAEK VIRLSDKRKR INFVYQDSDF IEEKIKKVAT 450
    IIYGAKDVKF SKAALSKLEL IKNLKVEHFP ICMSKTQYSL SDDPKLLGKP 500
    KDFILNVTDI EIKNGAGFIV VMCGDIIAMP GLGKDFAALH LDIDSSGNPI 550
    FK 552
    Length:552
    Mass (Da):59,985
    Last modified:March 24, 2009 - v1
    Checksum:i92CED9E624C09A5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001393 Genomic DNA. Translation: ACM61282.1.
    RefSeqiWP_015908543.1. NC_012034.1.
    YP_002574055.1. NC_012034.1.

    Genome annotation databases

    EnsemblBacteriaiACM61282; ACM61282; Athe_2208.
    GeneIDi7408404.
    KEGGiate:Athe_2208.
    PATRICi20901682. VBIAnaThe135187_2326.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001393 Genomic DNA. Translation: ACM61282.1 .
    RefSeqi WP_015908543.1. NC_012034.1.
    YP_002574055.1. NC_012034.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 521460.Athe_2208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM61282 ; ACM61282 ; Athe_2208 .
    GeneIDi 7408404.
    KEGGi ate:Athe_2208.
    PATRICi 20901682. VBIAnaThe135187_2326.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CBES521460:GH8H-2254-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1888 / DSM 6725 / Z-1320.

    Entry informationi

    Entry nameiFTHS_CALBD
    AccessioniPrimary (citable) accession number: B9MM59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3