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B9MM59 (FTHS_CALBD) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Athe_2208
OrganismCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum) [Complete proteome] [HAMAP]
Taxonomic identifier521460 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000185243

Regions

Nucleotide binding63 – 708ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B9MM59 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 92CED9E624C09A5A

FASTA55259,985
        10         20         30         40         50         60 
MKSISKVEEV LEPISKIAEK IGLDEDEIEL YGKYKAKISL DILKKKAQLQ EGKVILVTSI 

        70         80         90        100        110        120 
NPTPFGEGKT TTAIGLSMAI NRLGFKSIVT LREPSLGPFL GLKGGATGGG ASQILPSIDI 

       130        140        150        160        170        180 
NLHFTGDIHA VTSANNLLCA AVDNHIYHGN RLGINPKSIT IKRAMDMNDR SLRHIIVGLS 

       190        200        210        220        230        240 
NDQKGAIRED GFVISVASEV MAVLCLSMSY DDLKEKLGNI LVGFTYDKKP VYAKDLNVHG 

       250        260        270        280        290        300 
SMALLLKDAL KPNLVQTSEN TAAIVHGGPF ANIAHGTNSI VATKIAQKLS EYVVVEAGFG 

       310        320        330        340        350        360 
SDLGAEKFIN IVARKSGIYP QAAVLVVTVK ALKHHAKIEE NSGLQSGVNS IQQGLENLEK 

       370        380        390        400        410        420 
HIENLKVMGL ETVVALNKFP DDKDEEIELI RSFCEEMGVE FSVSSAYTHG SEGVLELAEK 

       430        440        450        460        470        480 
VIRLSDKRKR INFVYQDSDF IEEKIKKVAT IIYGAKDVKF SKAALSKLEL IKNLKVEHFP 

       490        500        510        520        530        540 
ICMSKTQYSL SDDPKLLGKP KDFILNVTDI EIKNGAGFIV VMCGDIIAMP GLGKDFAALH 

       550 
LDIDSSGNPI FK 

« Hide

References

[1]"Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1888 / DSM 6725 / Z-1320.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001393 Genomic DNA. Translation: ACM61282.1.
RefSeqYP_002574055.1. NC_012034.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING521460.Athe_2208.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM61282; ACM61282; Athe_2208.
GeneID7408404.
KEGGate:Athe_2208.
PATRIC20901682. VBIAnaThe135187_2326.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OrthoDBEOG6PCPSP.
ProtClustDBCLSK2472987.

Enzyme and pathway databases

BioCycCBES521460:GH8H-2254-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameFTHS_CALBD
AccessionPrimary (citable) accession number: B9MM59
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: April 16, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways