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B9ML76

- PAND_CALBD

UniProt

B9ML76 - PAND_CALBD

Protein

Aspartate 1-decarboxylase

Gene

panD

Organism
Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.UniRule annotation

    Catalytic activityi

    L-aspartate = beta-alanine + CO2.UniRule annotation

    Cofactori

    Pyruvoyl group.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei25 – 251Schiff-base intermediate with substrate; via pyruvic acidUniRule annotation
    Binding sitei57 – 571SubstrateUniRule annotation
    Active sitei58 – 581Proton donorUniRule annotation

    GO - Molecular functioni

    1. aspartate 1-decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. alanine biosynthetic process Source: InterPro
    2. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    Pyruvate, Schiff base

    Enzyme and pathway databases

    BioCyciCBES521460:GH8H-2020-MONOMER.
    UniPathwayiUPA00028; UER00002.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aspartate 1-decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation)
    Alternative name(s):
    Aspartate alpha-decarboxylaseUniRule annotation
    Cleaved into the following 2 chains:
    Aspartate 1-decarboxylase beta chainUniRule annotation
    Aspartate 1-decarboxylase alpha chainUniRule annotation
    Gene namesi
    Name:panDUniRule annotation
    Ordered Locus Names:Athe_1979
    OrganismiCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
    Taxonomic identifieri521460 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
    ProteomesiUP000007723: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2424Aspartate 1-decarboxylase beta chainUniRule annotationPRO_1000191918Add
    BLAST
    Chaini25 – 128104Aspartate 1-decarboxylase alpha chainUniRule annotationPRO_1000191919Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei25 – 251Pyruvic acid (Ser)UniRule annotation

    Post-translational modificationi

    Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.UniRule annotation

    Keywords - PTMi

    Autocatalytic cleavage, Zymogen

    Interactioni

    Subunit structurei

    Heterooctamer of four alpha and four beta subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi521460.Athe_1979.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni73 – 753Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PanD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0853.
    HOGENOMiHOG000221007.
    KOiK01579.
    OrthoDBiEOG6P5ZMC.

    Family and domain databases

    HAMAPiMF_00446. PanD.
    InterProiIPR009010. Asp_de-COase-like_dom.
    IPR003190. Asp_decarbox.
    [Graphical view]
    PANTHERiPTHR21012. PTHR21012. 1 hit.
    PfamiPF02261. Asp_decarbox. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006246. Asp_decarbox. 1 hit.
    ProDomiPD009294. Asp_decarbox. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    TIGRFAMsiTIGR00223. panD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B9ML76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFIEVLKSKI HRATVTEANL NYVGSITIDE ELMKAAGIYE NEKVQVVNIN    50
    NGERFETYVI KGEKGSGTIC LNGAAARLVQ VGDKIIIMAY CLLTMEEYYN 100
    HKPRIVFVDD ENKIVRLSDK EEHSECIC 128
    Length:128
    Mass (Da):14,489
    Last modified:March 24, 2009 - v1
    Checksum:iE9B4A3409EE98A86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001393 Genomic DNA. Translation: ACM61066.1.
    RefSeqiWP_015908351.1. NC_012034.1.
    YP_002573839.1. NC_012034.1.

    Genome annotation databases

    EnsemblBacteriaiACM61066; ACM61066; Athe_1979.
    GeneIDi7407395.
    KEGGiate:Athe_1979.
    PATRICi20901164. VBIAnaThe135187_2073.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001393 Genomic DNA. Translation: ACM61066.1 .
    RefSeqi WP_015908351.1. NC_012034.1.
    YP_002573839.1. NC_012034.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 521460.Athe_1979.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM61066 ; ACM61066 ; Athe_1979 .
    GeneIDi 7407395.
    KEGGi ate:Athe_1979.
    PATRICi 20901164. VBIAnaThe135187_2073.

    Phylogenomic databases

    eggNOGi COG0853.
    HOGENOMi HOG000221007.
    KOi K01579.
    OrthoDBi EOG6P5ZMC.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00002 .
    BioCyci CBES521460:GH8H-2020-MONOMER.

    Family and domain databases

    HAMAPi MF_00446. PanD.
    InterProi IPR009010. Asp_de-COase-like_dom.
    IPR003190. Asp_decarbox.
    [Graphical view ]
    PANTHERi PTHR21012. PTHR21012. 1 hit.
    Pfami PF02261. Asp_decarbox. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006246. Asp_decarbox. 1 hit.
    ProDomi PD009294. Asp_decarbox. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    TIGRFAMsi TIGR00223. panD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725."
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1888 / DSM 6725 / Z-1320.

    Entry informationi

    Entry nameiPAND_CALBD
    AccessioniPrimary (citable) accession number: B9ML76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3