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B9MKR9 (UPPP_CALBD) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Athe_1834
OrganismCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum) [Complete proteome] [HAMAP]
Taxonomic identifier521460 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148799

Regions

Transmembrane14 – 3421Helical; Potential
Transmembrane40 – 6021Helical; Potential
Transmembrane79 – 9921Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane141 – 16121Helical; Potential
Transmembrane182 – 20221Helical; Potential
Transmembrane217 – 23721Helical; Potential
Transmembrane242 – 26221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B9MKR9 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: BF47DCDED60B7B6D

FASTA26529,305
        10         20         30         40         50         60 
MTTFQAIFLG ILQGLGEFLP ISSSAHLIIF PWLFGWKEHS LVFDVALHLG TLLAVLVYFW 

        70         80         90        100        110        120 
KDYLDIVVQG IAKPKSEKGK LFWFIIVATI PGALFGYLFE NIVEEVFRKQ YLLIAIVLAV 

       130        140        150        160        170        180 
FGFILYYVDS IAKNKIELSK MNVFQAALIG VSQAFALFPG ISRSGITMTT GLLLGLKKEA 

       190        200        210        220        230        240 
AAKFSFLMSA PIILGAGAVS LLKNINHVSA EFSNFAIGFF TSAVVGFLAI HFLLGIVKKS 

       250        260 
GFKIFAYYRF FLAAVILAFY LLRAV 

« Hide

References

[1]"Complete sequence of chromosome of Anaerocellum thermophilum DSM 6725."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Meincke L., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kataeva I., Adams M.W.W.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1888 / DSM 6725 / Z-1320.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001393 Genomic DNA. Translation: ACM60927.1.
RefSeqYP_002573700.1. NC_012034.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING521460.Athe_1834.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM60927; ACM60927; Athe_1834.
GeneID7408948.
KEGGate:Athe_1834.
PATRIC20900852. VBIAnaThe135187_1920.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OrthoDBEOG6QP13M.
ProtClustDBCLSK2473598.

Enzyme and pathway databases

BioCycCBES521460:GH8H-1873-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CALBD
AccessionPrimary (citable) accession number: B9MKR9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families