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Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per monomer.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (Athe_1693)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80Anthranilate 1; via carbonyl oxygenUniRule annotation1
Binding sitei80Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei88PhosphoribosylpyrophosphateUniRule annotation1
Metal bindingi92Magnesium 1UniRule annotation1
Binding sitei111Anthranilate 1UniRule annotation1
Binding sitei120Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation1
Binding sitei166Anthranilate 2UniRule annotation1
Metal bindingi224Magnesium 2UniRule annotation1
Metal bindingi225Magnesium 1UniRule annotation1
Metal bindingi225Magnesium 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
Gene namesi
Name:trpDUniRule annotation
Ordered Locus Names:Athe_1694
OrganismiCaldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) (Anaerocellum thermophilum)
Taxonomic identifieri521460 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisCaldicellulosiruptor
Proteomesi
  • UP000007723 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001987971 – 336Anthranilate phosphoribosyltransferaseAdd BLAST336

Proteomic databases

PRIDEiB9MKD0.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi521460.Athe_1694.

Structurei

3D structure databases

ProteinModelPortaliB9MKD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni83 – 84Phosphoribosylpyrophosphate bindingUniRule annotation2
Regioni90 – 93Phosphoribosylpyrophosphate bindingUniRule annotation4
Regioni108 – 116Phosphoribosylpyrophosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiMIVLNAG.
OrthoDBiPOG091H01QX.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

B9MKD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIDVLELVT NKKDLEYDQV KNLLDNILEG ELDEIKFGAF LAALKTKGET
60 70 80 90 100
EKEISAFVDA FYDKAKKLNF DHPATIDTCG TGGDGKGTFN ISTAAAIVLS
110 120 130 140 150
CFDVKVAKHG NRSITSNSGS ADILEKLGID IQAEEDKILK GLEKLNFAFL
160 170 180 190 200
FAPLYHPAMK KVANLRRSLG IRTVFNILGP LLNPVPLKYQ VVGTFSFDAQ
210 220 230 240 250
DKVASVLRGN RKKAAVIHSL DGLDEISISQ KTRVLEIQDK NIKEYYIDPK
260 270 280 290 300
DYGIKFDTNS IRGFSPEENA RILISVLEGE KSPYFWAVVL NCGFALYICE
310 320 330
VAKDVEEGIK LSSKAIESKK AYLKLKELRQ FYKSGV
Length:336
Mass (Da):37,316
Last modified:March 24, 2009 - v1
Checksum:iBF5DCD73E5EF9A73
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001393 Genomic DNA. Translation: ACM60788.1.
RefSeqiWP_015908118.1. NC_012034.1.

Genome annotation databases

EnsemblBacteriaiACM60788; ACM60788; Athe_1694.
KEGGiate:Athe_1694.
PATRICi20900556. VBIAnaThe135187_1779.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001393 Genomic DNA. Translation: ACM60788.1.
RefSeqiWP_015908118.1. NC_012034.1.

3D structure databases

ProteinModelPortaliB9MKD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi521460.Athe_1694.

Proteomic databases

PRIDEiB9MKD0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM60788; ACM60788; Athe_1694.
KEGGiate:Athe_1694.
PATRICi20900556. VBIAnaThe135187_1779.

Phylogenomic databases

eggNOGiENOG4108I0Q. Bacteria.
COG0547. LUCA.
HOGENOMiHOG000230451.
KOiK00766.
OMAiMIVLNAG.
OrthoDBiPOG091H01QX.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00041.

Family and domain databases

Gene3Di3.40.1030.10. 2 hits.
HAMAPiMF_00211. TrpD. 1 hit.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPD_CALBD
AccessioniPrimary (citable) accession number: B9MKD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.