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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:Dtpsy_1368
OrganismiAcidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Taxonomic identifieri535289 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000000450 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001468391 – 398Nicotinate phosphoribosyltransferaseAdd BLAST398

Interactioni

Protein-protein interaction databases

STRINGi535289.Dtpsy_1368

Structurei

3D structure databases

ProteinModelPortaliB9MHC7
SMRiB9MHC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

B9MHC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIITSLLDTD LYKFTMMQVV LHQFPGAQVE YRFKCRNPGV ELAPFVSEIR
60 70 80 90 100
DEIRALCSLQ FQDAELAYLR SLRFIKSDFV DFLGLFRLNE KYIRVSALPS
110 120 130 140 150
GEIDITITGP WLHTILFEIP VLAIVNEVYF RNTQKVPDFP EGRRRLEAKI
160 170 180 190 200
GQLQQPGLDS LKIADYGTRR RFSRAWHEEV LRVLCVRLGS DDRRGAPGQF
210 220 230 240 250
AGTSNVLYAM KLGVTPLGTM AHEYLQACQS LGPRLRDSQV FGFEMWAKEY
260 270 280 290 300
RGDLGIALSD VYGMSAFLRD FDLYFCKLFD GARHDSGDPF AWGERLLQHY
310 320 330 340 350
RDNRVDPLTK TLIFSDALTV PRIIELYQRF NGRCQLAFGI GTNLTNDLGY
360 370 380 390
EPLQIVIKMT RCNGQPVAKL SDAPGKNMCN DEKYLAYLRQ VFEIPSPQ
Length:398
Mass (Da):45,542
Last modified:March 24, 2009 - v1
Checksum:iDA75F212BA1D6045
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001392 Genomic DNA Translation: ACM32832.1
RefSeqiWP_011805692.1, NC_011992.1

Genome annotation databases

EnsemblBacteriaiACM32832; ACM32832; Dtpsy_1368
KEGGidia:Dtpsy_1368

Similar proteinsi

Entry informationi

Entry nameiPNCB_ACIET
AccessioniPrimary (citable) accession number: B9MHC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: April 25, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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