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B9MFI6 (UPPP_ACIET) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Dtpsy_1072
OrganismAcidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY)) [Complete proteome] [HAMAP]
Taxonomic identifier535289 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148811

Regions

Transmembrane44 – 6421Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane109 – 12921Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane215 – 23521Helical; Potential
Transmembrane250 – 27021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B9MFI6 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: DBB1098DEAC58534

FASTA27429,649
        10         20         30         40         50         60 
MDTLLLLKAA IMGVVEGLTE FLPISSTGHL ILAGSLLGFD DAKAKVFDIA IQTGAIFAVI 

        70         80         90        100        110        120 
LVYWQRIRAT LVALPTERQA RRFALNVLIG FLPAVLLGLL LGKAIKAHLF TPVVVASTFI 

       130        140        150        160        170        180 
LGGFVILWAE RRQQAAVRIH AVDDMTPLDA LKVGLVQCLA MVPGTSRSGA TIIGGMLLGL 

       190        200        210        220        230        240 
SRKAATDYSF FLAIPTLIGA GVYSLYKERA LLSAADIPLF AVGLVFSFIS AWLCVRWLLR 

       250        260        270 
YISSHSFVPF AWYRIAFGLV VLVTAWSGLV TWAE 

« Hide

References

[1]"Complete sequence of Diaphorobacter sp. TPSY."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Coates J.D.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TPSY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001392 Genomic DNA. Translation: ACM32549.1.
RefSeqYP_002552549.1. NC_011992.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING535289.Dtpsy_1072.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM32549; ACM32549; Dtpsy_1072.
GeneID7382881.
KEGGdia:Dtpsy_1072.
PATRIC21779192. VBIDiaSp55748_1103.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAVIYFRNE.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycAEBR535289:GHOO-1082-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_ACIET
AccessionPrimary (citable) accession number: B9MFI6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families