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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciAEBR535289:G1GUT-2935-MONOMER
UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:Dtpsy_2904
OrganismiAcidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Taxonomic identifieri535289 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
Proteomesi
  • UP000000450 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002010171 – 434Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei274N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB9MF68

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi535289.Dtpsy_2904

Structurei

3D structure databases

ProteinModelPortaliB9MF68
SMRiB9MF68
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit

Sequencei

Sequence statusi: Complete.

B9MF68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHNTDLNLP LFERAKALIP GGVNSPVRAF RAVGGTPRFI TRAQGAYMWD
60 70 80 90 100
ANGQRFIDYI GSWGPMILGH GHPAVLEAVQ KAALEGFSFG APTEREVELA
110 120 130 140 150
EEIIRHVPSM EMIRLVSSGT EAGMSAIRLA RGATRRNKII KFNGCYHGHA
160 170 180 190 200
DSLLVKAGSG LATFGHATSA GVPQEVVQHT LVLEYNDVAQ LEEAFTLHGP
210 220 230 240 250
DVACVIMEPI AGNMNFVRAS VPFMRRAREL CTQHGALLVI DEVMTGFRVA
260 270 280 290 300
LGGAQSLYAQ AIPGFKPDIT VLGKVIGGGM PLAAFGGSRA VMEQLAPLGP
310 320 330 340 350
VYQAGTLSGN PVATACGLAT LREIAKPGFY DALGARTRAL IDGLAGAASA
360 370 380 390 400
AGVPFCGDTQ GGMFGFFLLP QLPQNYPEVL NTDGMRFNTL FHGLLDGGVY
410 420 430
IAPALYEAGF VSAAHTEQDI ADTVAVARDV FQKL
Length:434
Mass (Da):45,949
Last modified:March 24, 2009 - v1
Checksum:iDF6CC7922242EB94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001392 Genomic DNA Translation: ACM34338.1
RefSeqiWP_015914198.1, NC_011992.1

Genome annotation databases

EnsemblBacteriaiACM34338; ACM34338; Dtpsy_2904
KEGGidia:Dtpsy_2904

Similar proteinsi

Entry informationi

Entry nameiGSA_ACIET
AccessioniPrimary (citable) accession number: B9MF68
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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