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B9ME49

- ISPE_ACIET

UniProt

B9ME49 - ISPE_ACIET

Protein

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Gene

ispE

Organism
Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.UniRule annotation

    Catalytic activityi

    ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei12 – 121UniRule annotation
    Active sitei136 – 1361UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi94 – 10411ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Isoprene biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAEBR535289:GHOO-830-MONOMER.
    UniPathwayiUPA00056; UER00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-diphosphocytidyl-2-C-methyl-D-erythritol kinaseUniRule annotation (EC:2.7.1.148UniRule annotation)
    Short name:
    CMKUniRule annotation
    Alternative name(s):
    4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinaseUniRule annotation
    Gene namesi
    Name:ispEUniRule annotation
    Ordered Locus Names:Dtpsy_0825
    OrganismiAcidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
    Taxonomic identifieri535289 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
    ProteomesiUP000000450: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2832834-diphosphocytidyl-2-C-methyl-D-erythritol kinasePRO_1000190685Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi535289.Dtpsy_0825.

    Structurei

    3D structure databases

    ProteinModelPortaliB9ME49.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GHMP kinase family. IspE subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1947.
    HOGENOMiHOG000019601.
    KOiK00919.
    OMAiCFALFNE.
    OrthoDBiEOG62VNQ2.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00061. IspE.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR004424. IspE.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR20861:SF2. PTHR20861:SF2. 1 hit.
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF010376. IspE. 1 hit.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00154. ispE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9ME49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQALYDVPAP AKLNLFLHVT GRRPDGYHLL QSVFMLIDWC DVLHFEVRGN    50
    GTVTREDLTS ALPADDLVVR AARALQKATG CPQGVHIGVS KHIPAQAGLG 100
    GGSSDAASTL LALNRLWKLK LSRQQLHSIA LTLGADVPFF LCGASAWVEG 150
    IGDIIRRLEL EHQLPPAAFA VVKPEAGLDT RMIFSHPSLK RDSSCATISG 200
    FAATHYQFGS NDLQPVAQAL CPEITQAINW LESKGLQGRM TGSGSAVFAQ 250
    ITHAVDLHDA PAAWHVKVCE NLKSHPLADW VFG 283
    Length:283
    Mass (Da):30,491
    Last modified:March 24, 2009 - v1
    Checksum:iA0BD966CAA7B8BA2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001392 Genomic DNA. Translation: ACM32303.1.
    RefSeqiYP_002552303.1. NC_011992.1.

    Genome annotation databases

    EnsemblBacteriaiACM32303; ACM32303; Dtpsy_0825.
    GeneIDi7383520.
    KEGGidia:Dtpsy_0825.
    PATRICi21778682. VBIDiaSp55748_0852.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001392 Genomic DNA. Translation: ACM32303.1 .
    RefSeqi YP_002552303.1. NC_011992.1.

    3D structure databases

    ProteinModelPortali B9ME49.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 535289.Dtpsy_0825.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM32303 ; ACM32303 ; Dtpsy_0825 .
    GeneIDi 7383520.
    KEGGi dia:Dtpsy_0825.
    PATRICi 21778682. VBIDiaSp55748_0852.

    Phylogenomic databases

    eggNOGi COG1947.
    HOGENOMi HOG000019601.
    KOi K00919.
    OMAi CFALFNE.
    OrthoDBi EOG62VNQ2.

    Enzyme and pathway databases

    UniPathwayi UPA00056 ; UER00094 .
    BioCyci AEBR535289:GHOO-830-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00061. IspE.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR004424. IspE.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR20861:SF2. PTHR20861:SF2. 1 hit.
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF010376. IspE. 1 hit.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00154. ispE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TPSY.

    Entry informationi

    Entry nameiISPE_ACIET
    AccessioniPrimary (citable) accession number: B9ME49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3