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B9MCU3 (B9MCU3_ACIET) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800
Gene names
Ordered Locus Names:Dtpsy_2439
OrganismAcidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY)) [Complete proteome] [HAMAP] EMBL ACM33875.1
Taxonomic identifier535289 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax ›

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800

Catalytic activity

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800

L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800

Cofactor

Pyridoxal phosphate By similarity. PIRNR PIRNR038800

Pathway

Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800

Subunit structure

Homodimer By similarity. PIRNR PIRNR038800

Sequence similarities

Belongs to the kynureninase family. PIRNR PIRNR038800

Sequences

Sequence LengthMass (Da)Tools
B9MCU3 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: D948CEFABB3F945D

FASTA43747,110
        10         20         30         40         50         60 
MTTLQECRTR DAQDPLRSLR DHFSLPEGVI YLDGNSLGAL PRATPARVAQ VVQQEWGQDL 

        70         80         90        100        110        120 
ITSWNKAGWV SLPQRLGNQF APWIGAGPDQ VVFTDTTSVN LYKVLSAAAR VARADHPGRT 

       130        140        150        160        170        180 
QLVSERSNFP TDLYIAQSVC QEYGLELVLV EPEEIATRLT PQVAVLLLTH VNYRTGAMHD 

       190        200        210        220        230        240 
MAAVTAQAHA HGILCVWDLC HSAGAVPVHL LDANADYAVG CSYKYLNGGP GAPAFVWVHP 

       250        260        270        280        290        300 
RLADRPGATF AQPLSGWFGH AAPFAFTPDY QPAPGIARYL CGTQPIVSLS ALQCGLDIFT 

       310        320        330        340        350        360 
AAEPLGGMAA LRAKSLALTD LFIALVEEHC AGHGLELATP RDHAARGSQV CLTRGEGLGV 

       370        380        390        400        410        420 
QGVGSGAYAI VQALIARGVV GDFRKGDGGK HLDILRFGFT PLYVGFEDVW NAVQHLRQVL 

       430 
ESGEWRKPEF NHLNAVT

« Hide

References

[1]"Complete sequence of Diaphorobacter sp. TPSY."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Coates J.D.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TPSY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001392 Genomic DNA. Translation: ACM33875.1.
RefSeqYP_002553875.1. NC_011992.1.

3D structure databases

ProteinModelPortalB9MCU3.
ModBaseSearch...

Protein-protein interaction databases

STRING535289.Dtpsy_2439.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM33875; ACM33875; Dtpsy_2439.
GeneID7383941.
KEGGdia:Dtpsy_2439.
PATRIC21781999. VBIDiaSp55748_2474.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3844.
HOGENOMHOG000242437.
KOK01556.
OMAMLTHVNY.
ProtClustDBCLSK953241.

Enzyme and pathway databases

BioCycAEBR535289:GHOO-2481-MONOMER.
UniPathwayUPA00253; UER00329.
UPA00334; UER00455.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR14084. PTHR14084. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFPIRSF038800. KYNU. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMsTIGR01814. kynureninase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB9MCU3_ACIET
AccessionPrimary (citable) accession number: B9MCU3
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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