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B9MBT7 (GLPK_ACIET) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:Dtpsy_0373
OrganismAcidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY)) [Complete proteome] [HAMAP]
Taxonomic identifier535289 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Glycerol kinase HAMAP MF_00186
PRO_1000124191

Regions

Nucleotide binding412 – 4165ATP By similarity

Sites

Binding site111Substrate By similarity
Binding site151ATP By similarity
Binding site811Substrate By similarity
Binding site1331Substrate By similarity
Binding site2421Substrate By similarity
Binding site2641ATP By similarity
Binding site3071ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
B9MBT7 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 432D0E71010A70B4

FASTA49853,238
        10         20         30         40         50         60 
MTYLLALDQG TSSSRSIVFD ERGRIVAQAQ RELPQIYPRP GWVEHDPREI WRTQLATAQD 

        70         80         90        100        110        120 
ALREARITAQ DVRALGITNQ RETTVLWNRR TGQPVHHAIV WQDRRAEPAC AQLREQGHAA 

       130        140        150        160        170        180 
AIQAKTGLLI DAYFSGTKLQ WLLDHVPGAR DAAEAGELAF GTVDSWLIWQ LTGGTRHVTD 

       190        200        210        220        230        240 
VSNASRTMLF NVHTNQWDDE LLQLLRIPRA LMPEVLPSAS DFGATDAALL GGPIAIGGVA 

       250        260        270        280        290        300 
GDQQSALFGQ ACFTAGMAKN TYGTGCFMLM HTGSRFQKSE NGLLTTSAAQ ASRSPEYAME 

       310        320        330        340        350        360 
GSVFVGGAVV QWLRDGLRAI SASSEVQALA ESVPDSGGVM MVPAFTGLGA PYWKPDARGT 

       370        380        390        400        410        420 
ITGLTRGTTI AHIARAALES IAYQSAALLA AMSRDAVAAG GAPVSELRVD GGACVNDLLM 

       430        440        450        460        470        480 
QFQADLLGIP VVRPAVVETT ALGAAYLAGL ASGVYASTDE LSALWQAERR FTPTLPRSQA 

       490 
EALMARWEHA VAQAVLPG

« Hide

References

[1]"Complete sequence of Diaphorobacter sp. TPSY."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Coates J.D.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TPSY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001392 Genomic DNA. Translation: ACM31857.1.
RefSeqYP_002551857.1. NC_011992.1.

3D structure databases

ProteinModelPortalB9MBT7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB9MBT7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7385381.
GenomeReviewsGene locus Dtpsy_0373 in contig CP001392_GR.
KEGGdia:Dtpsy_0373.
PATRIC21777742. VBIDiaSp55748_0387.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAATYFSGT.
ProtClustDBCLSK897540.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_ACIET
AccessionPrimary (citable) accession number: B9MBT7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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