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Protein

4-hydroxybenzoate octaprenyltransferase

Gene

ubiA

Organism
Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.UniRule annotation

Catalytic activityi

4-hydroxybenzoate + farnesylfarnesylgeraniol = 3-octaprenyl-4-hydroxybenzoate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathway: ubiquinone biosynthesis

This protein is involved in the pathway ubiquinone biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway ubiquinone biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Ubiquinone biosynthesis

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciAEBR535289:GHOO-372-MONOMER.
UniPathwayiUPA00232.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxybenzoate octaprenyltransferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Alternative name(s):
4-HB polyprenyltransferaseUniRule annotation
Gene namesi
Name:ubiAUniRule annotation
Ordered Locus Names:Dtpsy_0371
OrganismiAcidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY))
Taxonomic identifieri535289 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesComamonadaceaeAcidovorax
ProteomesiUP000000450 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4020HelicalUniRule annotationAdd
BLAST
Transmembranei45 – 6420HelicalUniRule annotationAdd
BLAST
Transmembranei91 – 11121HelicalUniRule annotationAdd
BLAST
Transmembranei116 – 13621HelicalUniRule annotationAdd
BLAST
Transmembranei138 – 15821HelicalUniRule annotationAdd
BLAST
Transmembranei165 – 18521HelicalUniRule annotationAdd
BLAST
Transmembranei212 – 23221HelicalUniRule annotationAdd
BLAST
Transmembranei237 – 25721HelicalUniRule annotationAdd
BLAST
Transmembranei269 – 28921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2902904-hydroxybenzoate octaprenyltransferasePRO_1000186662Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi535289.Dtpsy_0371.

Family & Domainsi

Sequence similaritiesi

Belongs to the UbiA prenyltransferase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0382.
HOGENOMiHOG000003696.
KOiK03179.
OMAiAFSWAIP.
OrthoDBiEOG680X3B.

Family and domain databases

HAMAPiMF_01635. UbiA.
InterProiIPR031103. HB_octoprenylTrfase.
IPR006370. HB_polyprenyltransferase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9MBT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAVAPRSRL SLYLDLIRWN RPAGWLVLVW PTLAALWVAA DGFPGWHLLA
60 70 80 90 100
VFVAGTVLMR SAGCTINDIA DRDFDRHVKR TTQRPITSGQ LGVREAALVG
110 120 130 140 150
VVLTLVAFVL VLTTRWEAVA WSVPAVLFTI LYPFTKRFFA MPQAFLGIAF
160 170 180 190 200
NFGIVIAFAA VQGRVPATAW VLWLANLFLV LAYDTEYAMV DRDDDLKIGM
210 220 230 240 250
KTSAITLGRF DVAAIMGFFV LCLGLTAWVL APYGLGWPLW LGLGVAAAQV
260 270 280 290
AWHFTLIKDR TREGCFTAFS KSHWIGAAIF AGVALGYLLR
Length:290
Mass (Da):31,925
Last modified:March 24, 2009 - v1
Checksum:i25501D3A6D1BE78D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001392 Genomic DNA. Translation: ACM31855.1.
RefSeqiWP_011803842.1. NC_011992.1.
YP_002551855.1. NC_011992.1.

Genome annotation databases

EnsemblBacteriaiACM31855; ACM31855; Dtpsy_0371.
KEGGidia:Dtpsy_0371.
PATRICi21777738. VBIDiaSp55748_0385.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001392 Genomic DNA. Translation: ACM31855.1.
RefSeqiWP_011803842.1. NC_011992.1.
YP_002551855.1. NC_011992.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi535289.Dtpsy_0371.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM31855; ACM31855; Dtpsy_0371.
KEGGidia:Dtpsy_0371.
PATRICi21777738. VBIDiaSp55748_0385.

Phylogenomic databases

eggNOGiCOG0382.
HOGENOMiHOG000003696.
KOiK03179.
OMAiAFSWAIP.
OrthoDBiEOG680X3B.

Enzyme and pathway databases

UniPathwayiUPA00232.
BioCyciAEBR535289:GHOO-372-MONOMER.

Family and domain databases

HAMAPiMF_01635. UbiA.
InterProiIPR031103. HB_octoprenylTrfase.
IPR006370. HB_polyprenyltransferase.
IPR000537. UbiA_prenyltransferase.
IPR030470. UbiA_prenylTrfase_CS.
[Graphical view]
PfamiPF01040. UbiA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01474. ubiA_proteo. 1 hit.
PROSITEiPS00943. UBIA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TPSY.

Entry informationi

Entry nameiUBIA_ACIET
AccessioniPrimary (citable) accession number: B9MBT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: June 24, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.