B9MBT5 (UBIA_ACIET) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxybenzoate octaprenyltransferase
EC=2.5.1.-

Alternative name(s):
4-HB polyprenyltransferase

Gene names

Name:	ubiA
Ordered Locus Names:	Dtpsy_0371

Organism

Acidovorax ebreus (strain TPSY) (Diaphorobacter sp. (strain TPSY)) [Complete proteome] [HAMAP]

Taxonomic identifier

535289 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Comamonadaceae › Acidovorax › Acidovorax ebreus

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesis of 3-octaprenyl-4-hydroxybenzoate By similarity. HAMAP-Rule MF_01635
Catalytic activity	4-hydroxybenzoate + farnesylfarnesylgeraniol = 3-octaprenyl-4-hydroxybenzoate. HAMAP-Rule MF_01635
Cofactor	Magnesium By similarity.
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP-Rule MF_01635
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01635.
Sequence similarities	Belongs to the UbiA prenyltransferase family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Magnesium
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	4-hydroxybenzoate octaprenyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	4-hydroxybenzoate octaprenyltransferase HAMAP-Rule MF_01635		PRO_1000186662
Regions
	Transmembrane	21 – 40	20	Helical; Potential
	Transmembrane	45 – 64	20	Helical; Potential
	Transmembrane	91 – 111	21	Helical; Potential
	Transmembrane	116 – 136	21	Helical; Potential
	Transmembrane	138 – 158	21	Helical; Potential
	Transmembrane	165 – 185	21	Helical; Potential
	Transmembrane	212 – 232	21	Helical; Potential
	Transmembrane	237 – 257	21	Helical; Potential
	Transmembrane	269 – 289	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B9MBT5 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 25501D3A6D1BE78D	FASTA	290	31,925
	10 20 30 40 50 60 MSAVAPRSRL SLYLDLIRWN RPAGWLVLVW PTLAALWVAA DGFPGWHLLA VFVAGTVLMR 70 80 90 100 110 120 SAGCTINDIA DRDFDRHVKR TTQRPITSGQ LGVREAALVG VVLTLVAFVL VLTTRWEAVA 130 140 150 160 170 180 WSVPAVLFTI LYPFTKRFFA MPQAFLGIAF NFGIVIAFAA VQGRVPATAW VLWLANLFLV 190 200 210 220 230 240 LAYDTEYAMV DRDDDLKIGM KTSAITLGRF DVAAIMGFFV LCLGLTAWVL APYGLGWPLW 250 260 270 280 290 LGLGVAAAQV AWHFTLIKDR TREGCFTAFS KSHWIGAAIF AGVALGYLLR

References

[1]

"Complete sequence of Diaphorobacter sp. TPSY." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Coates J.D. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TPSY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001392 Genomic DNA. Translation: ACM31855.1.
RefSeq	YP_002551855.1. NC_011992.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	535289.Dtpsy_0371.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACM31855; ACM31855; Dtpsy_0371.
GeneID	7385379.
KEGG	dia:Dtpsy_0371.
PATRIC	21777738. VBIDiaSp55748_0385.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0382.
HOGENOM	HOG000003696.
KO	K03179.
OMA	YHYTLIR.
ProtClustDB	CLSK951796.
Enzyme and pathway databases
BioCyc	AEBR535289:GHOO-372-MONOMER.
UniPathway	UPA00232.
Family and domain databases
HAMAP	MF_01635. UbiA.
InterPro	IPR006370. HB_polyprenyl-transferase. IPR000537. UbiA_prenyltransferase. [Graphical view]
Pfam	PF01040. UbiA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01474. ubiA_proteo. 1 hit.
PROSITE	PS00943. UBIA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIA_ACIET

Accession

Primary (citable) accession number: B9MBT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program