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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP316067:GHSV-2196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Geob_2171
OrganismiGeobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Taxonomic identifieri316067 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007721 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Leucine--tRNA ligasePRO_1000199208Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316067.Geob_2171.

Structurei

3D structure databases

ProteinModelPortaliB9M9F3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi581 – 5855"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9M9F3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEKYVPARV EEKWQKLWDS NKSFKAEKVE GKSKYYLLEM FPYPSGRIHM
60 70 80 90 100
GHVRNYSIGD VIARFKRMKG FNVLHPMGWD AFGMPAENAA IQHKSHPAKW
110 120 130 140 150
TYENIDYMRG QLKKMGFSYD WDRELATCNV EYYKWEQLIF LQMLEKGLAY
160 170 180 190 200
KKKSSVNWCP RCETVLANEQ VEDGSCWRCD SLVEQKELEQ WSFRITDYAE
210 220 230 240 250
ELLEDTYKLP GWPERVLTMQ RNWIGRSTGC EIDFSIEGRK DAIKVFTTRQ
260 270 280 290 300
DTLFGATFMS LAPEHPLALQ LTTAENMIVV NAFLDKVKKT DKIKRTAEDF
310 320 330 340 350
EKEGVFTGSY CINPVTNRRM PIYLANFVLT DYGTGAVMAV PTHDQRDFEF
360 370 380 390 400
ARKYAIAMEV VIQPEGGSLD VATMTEAYTA EGIMVNSGRF DGLNSAVAKE
410 420 430 440 450
QIADFLEQEG LGKKTVNFRL RDWGISRQRY WGNPIPVIYC DDCGAVPVPA
460 470 480 490 500
KDLPVVLPMD ATFTGEGGNP LSKIDSFIKT TCPLCGKDAR RETDTMDTFV
510 520 530 540 550
ESSWYFLRYC CPDFACGPLD KGKTEYWMSV DQYIGGIEHA VMHLLYARFF
560 570 580 590 600
TKVLRDLGYC DINEPFTNLL TQGMVIKDGS KMSKSKGNVV DPNALIEKYG
610 620 630 640 650
ADTARLFSLF AAPPEKDLDW SDQGVDGSYR FLNRVWKLVY ECLPLISATG
660 670 680 690 700
PLDAAALTDE GKTLRRLVHK TIRKVSDDIE DRFHFNTAIA AIMEMVNAIQ
710 720 730 740 750
AFEPKNQPRN VPVLKEAVES VVLLLAPFVP HFAEELWESL GHEDNLNEAA
760 770 780 790 800
WPAFDAAAAV DEELLVVVQV NGKLRGKVTV AASATDEDIK GAVLADEKIR
810 820
QLIDGMNIKK IVYVPGKLVN IVVG
Length:824
Mass (Da):93,327
Last modified:March 24, 2009 - v1
Checksum:i03B7E84C731369F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001390 Genomic DNA. Translation: ACM20525.1.
RefSeqiWP_012647254.1. NC_011979.1.
YP_002537626.1. NC_011979.1.

Genome annotation databases

EnsemblBacteriaiACM20525; ACM20525; Geob_2171.
KEGGigeo:Geob_2171.
PATRICi22010951. VBIGeoSp137169_2239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001390 Genomic DNA. Translation: ACM20525.1.
RefSeqiWP_012647254.1. NC_011979.1.
YP_002537626.1. NC_011979.1.

3D structure databases

ProteinModelPortaliB9M9F3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi316067.Geob_2171.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM20525; ACM20525; Geob_2171.
KEGGigeo:Geob_2171.
PATRICi22010951. VBIGeoSp137169_2239.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciGSP316067:GHSV-2196-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22248 / JCM 15807 / FRC-32.

Entry informationi

Entry nameiSYL_GEODF
AccessioniPrimary (citable) accession number: B9M9F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 27, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.