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B9M9F3

- SYL_GEODF

UniProt

B9M9F3 - SYL_GEODF

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Protein
Leucine--tRNA ligase
Gene
leuS, Geob_2171
Organism
Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciGSP316067:GHSV-2196-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Geob_2171
OrganismiGeobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Taxonomic identifieri316067 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007721: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 824824Leucine--tRNA ligaseUniRule annotation
PRO_1000199208Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316067.Geob_2171.

Structurei

3D structure databases

ProteinModelPortaliB9M9F3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotation
Add
BLAST
Motifi581 – 5855"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9M9F3-1 [UniParc]FASTAAdd to Basket

« Hide

MEEKYVPARV EEKWQKLWDS NKSFKAEKVE GKSKYYLLEM FPYPSGRIHM    50
GHVRNYSIGD VIARFKRMKG FNVLHPMGWD AFGMPAENAA IQHKSHPAKW 100
TYENIDYMRG QLKKMGFSYD WDRELATCNV EYYKWEQLIF LQMLEKGLAY 150
KKKSSVNWCP RCETVLANEQ VEDGSCWRCD SLVEQKELEQ WSFRITDYAE 200
ELLEDTYKLP GWPERVLTMQ RNWIGRSTGC EIDFSIEGRK DAIKVFTTRQ 250
DTLFGATFMS LAPEHPLALQ LTTAENMIVV NAFLDKVKKT DKIKRTAEDF 300
EKEGVFTGSY CINPVTNRRM PIYLANFVLT DYGTGAVMAV PTHDQRDFEF 350
ARKYAIAMEV VIQPEGGSLD VATMTEAYTA EGIMVNSGRF DGLNSAVAKE 400
QIADFLEQEG LGKKTVNFRL RDWGISRQRY WGNPIPVIYC DDCGAVPVPA 450
KDLPVVLPMD ATFTGEGGNP LSKIDSFIKT TCPLCGKDAR RETDTMDTFV 500
ESSWYFLRYC CPDFACGPLD KGKTEYWMSV DQYIGGIEHA VMHLLYARFF 550
TKVLRDLGYC DINEPFTNLL TQGMVIKDGS KMSKSKGNVV DPNALIEKYG 600
ADTARLFSLF AAPPEKDLDW SDQGVDGSYR FLNRVWKLVY ECLPLISATG 650
PLDAAALTDE GKTLRRLVHK TIRKVSDDIE DRFHFNTAIA AIMEMVNAIQ 700
AFEPKNQPRN VPVLKEAVES VVLLLAPFVP HFAEELWESL GHEDNLNEAA 750
WPAFDAAAAV DEELLVVVQV NGKLRGKVTV AASATDEDIK GAVLADEKIR 800
QLIDGMNIKK IVYVPGKLVN IVVG 824
Length:824
Mass (Da):93,327
Last modified:March 24, 2009 - v1
Checksum:i03B7E84C731369F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001390 Genomic DNA. Translation: ACM20525.1.
RefSeqiYP_002537626.1. NC_011979.1.

Genome annotation databases

EnsemblBacteriaiACM20525; ACM20525; Geob_2171.
GeneIDi7363271.
KEGGigeo:Geob_2171.
PATRICi22010951. VBIGeoSp137169_2239.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001390 Genomic DNA. Translation: ACM20525.1 .
RefSeqi YP_002537626.1. NC_011979.1.

3D structure databases

ProteinModelPortali B9M9F3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316067.Geob_2171.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM20525 ; ACM20525 ; Geob_2171 .
GeneIDi 7363271.
KEGGi geo:Geob_2171.
PATRICi 22010951. VBIGeoSp137169_2239.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci GSP316067:GHSV-2196-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22248 / JCM 15807 / FRC-32.

Entry informationi

Entry nameiSYL_GEODF
AccessioniPrimary (citable) accession number: B9M9F3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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