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B9M9F3

- SYL_GEODF

UniProt

B9M9F3 - SYL_GEODF

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei584 – 5841ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciGSP316067:GHSV-2196-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Geob_2171
    OrganismiGeobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
    Taxonomic identifieri316067 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000007721: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 824824Leucine--tRNA ligasePRO_1000199208Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316067.Geob_2171.

    Structurei

    3D structure databases

    ProteinModelPortaliB9M9F3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi581 – 5855"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9M9F3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEKYVPARV EEKWQKLWDS NKSFKAEKVE GKSKYYLLEM FPYPSGRIHM    50
    GHVRNYSIGD VIARFKRMKG FNVLHPMGWD AFGMPAENAA IQHKSHPAKW 100
    TYENIDYMRG QLKKMGFSYD WDRELATCNV EYYKWEQLIF LQMLEKGLAY 150
    KKKSSVNWCP RCETVLANEQ VEDGSCWRCD SLVEQKELEQ WSFRITDYAE 200
    ELLEDTYKLP GWPERVLTMQ RNWIGRSTGC EIDFSIEGRK DAIKVFTTRQ 250
    DTLFGATFMS LAPEHPLALQ LTTAENMIVV NAFLDKVKKT DKIKRTAEDF 300
    EKEGVFTGSY CINPVTNRRM PIYLANFVLT DYGTGAVMAV PTHDQRDFEF 350
    ARKYAIAMEV VIQPEGGSLD VATMTEAYTA EGIMVNSGRF DGLNSAVAKE 400
    QIADFLEQEG LGKKTVNFRL RDWGISRQRY WGNPIPVIYC DDCGAVPVPA 450
    KDLPVVLPMD ATFTGEGGNP LSKIDSFIKT TCPLCGKDAR RETDTMDTFV 500
    ESSWYFLRYC CPDFACGPLD KGKTEYWMSV DQYIGGIEHA VMHLLYARFF 550
    TKVLRDLGYC DINEPFTNLL TQGMVIKDGS KMSKSKGNVV DPNALIEKYG 600
    ADTARLFSLF AAPPEKDLDW SDQGVDGSYR FLNRVWKLVY ECLPLISATG 650
    PLDAAALTDE GKTLRRLVHK TIRKVSDDIE DRFHFNTAIA AIMEMVNAIQ 700
    AFEPKNQPRN VPVLKEAVES VVLLLAPFVP HFAEELWESL GHEDNLNEAA 750
    WPAFDAAAAV DEELLVVVQV NGKLRGKVTV AASATDEDIK GAVLADEKIR 800
    QLIDGMNIKK IVYVPGKLVN IVVG 824
    Length:824
    Mass (Da):93,327
    Last modified:March 24, 2009 - v1
    Checksum:i03B7E84C731369F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001390 Genomic DNA. Translation: ACM20525.1.
    RefSeqiYP_002537626.1. NC_011979.1.

    Genome annotation databases

    EnsemblBacteriaiACM20525; ACM20525; Geob_2171.
    GeneIDi7363271.
    KEGGigeo:Geob_2171.
    PATRICi22010951. VBIGeoSp137169_2239.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001390 Genomic DNA. Translation: ACM20525.1 .
    RefSeqi YP_002537626.1. NC_011979.1.

    3D structure databases

    ProteinModelPortali B9M9F3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316067.Geob_2171.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM20525 ; ACM20525 ; Geob_2171 .
    GeneIDi 7363271.
    KEGGi geo:Geob_2171.
    PATRICi 22010951. VBIGeoSp137169_2239.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci GSP316067:GHSV-2196-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 22248 / JCM 15807 / FRC-32.

    Entry informationi

    Entry nameiSYL_GEODF
    AccessioniPrimary (citable) accession number: B9M9F3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3