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B9M6H6 (SPEA_GEODF) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Geob_1678
OrganismGeobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32) [Complete proteome] [HAMAP]
Taxonomic identifier316067 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000184844

Regions

Region282 – 29211Substrate-binding Potential

Amino acid modifications

Modified residue1001N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B9M6H6 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: F80B33DABDF7CAD7

FASTA63571,555
        10         20         30         40         50         60 
MERWNINDSS KIYNLDNWGA DLFSINKKGN VCVHPSPSSK SSIDLRVLVD DLIKRKIKPP 

        70         80         90        100        110        120 
ILLRFMDVLQ GRIASINRAF KSAISENDYP AKYQTFFPIK VNQQRQVVEA IASYGKRYNI 

       130        140        150        160        170        180 
GLEVGSKPEL VAGISISSGN NLPIICNGYK DSEYIETVLY ATAIGYDITL VIEKLFELEK 

       190        200        210        220        230        240 
VIELVKKTGI QPRLGIRVKL SSKGTGKWAT SGGEDAKFGL RMSEIIAAID LLEENGLLDR 

       250        260        270        280        290        300 
VKLIHFHIGS QITKIDKIKT ALIEGARVYT ELRKMGMGIE FVDIGGGLGV DYDGSKSSYF 

       310        320        330        340        350        360 
SSVNYSVEEY ANDVIYQIKN ICDDAGVECP NIISESGRAT VAHYSVLVTN VLNTNTQRLT 

       370        380        390        400        410        420 
PDFEEELAAA EKLAPTVKKL VDIHKSIDRY SLREDYHDTV QLIQEAVSLF NLGYLTLNER 

       430        440        450        460        470        480 
AMAEWLYGKI IKKINSIVEK IKPIPEELQN FQLALRQTYF ANFSLFQSIP DSWAIDQLFP 

       490        500        510        520        530        540 
IVPIQRLNQK PDVIASIADI TCDSDGEITS FVGENGRTKF LPLHKIRKDE DYYIGFFLIG 

       550        560        570        580        590        600 
AYQEILGDMH NLFGDTNAVH ITFNKKTGYM IDTVINGDAC WESLKYVQYK GPEILKRVRE 

       610        620        630 
HLEKGVAQRK VSIEESSHFI ELLDRTLLGY TYLGE 

« Hide

References

[1]"Complete sequence of Geobacter sp. FRC-32."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kostka J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 22248 / JCM 15807 / FRC-32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001390 Genomic DNA. Translation: ACM20036.1.
RefSeqYP_002537137.1. NC_011979.1.

3D structure databases

ProteinModelPortalB9M6H6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316067.Geob_1678.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM20036; ACM20036; Geob_1678.
GeneID7362608.
KEGGgeo:Geob_1678.
PATRIC22009921. VBIGeoSp137169_1730.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OrthoDBEOG676Z0R.

Enzyme and pathway databases

BioCycGSP316067:GHSV-1696-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR01273. speA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPEA_GEODF
AccessionPrimary (citable) accession number: B9M6H6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways