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B9M6H6

- SPEA_GEODF

UniProt

B9M6H6 - SPEA_GEODF

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium.UniRule annotation
Pyridoxal phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciGSP316067:GHSV-1696-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:Geob_1678
OrganismiGeobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Taxonomic identifieri316067 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007721: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Biosynthetic arginine decarboxylasePRO_1000184844Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei100 – 1001N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi316067.Geob_1678.

Structurei

3D structure databases

ProteinModelPortaliB9M6H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni282 – 29211Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9M6H6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERWNINDSS KIYNLDNWGA DLFSINKKGN VCVHPSPSSK SSIDLRVLVD
60 70 80 90 100
DLIKRKIKPP ILLRFMDVLQ GRIASINRAF KSAISENDYP AKYQTFFPIK
110 120 130 140 150
VNQQRQVVEA IASYGKRYNI GLEVGSKPEL VAGISISSGN NLPIICNGYK
160 170 180 190 200
DSEYIETVLY ATAIGYDITL VIEKLFELEK VIELVKKTGI QPRLGIRVKL
210 220 230 240 250
SSKGTGKWAT SGGEDAKFGL RMSEIIAAID LLEENGLLDR VKLIHFHIGS
260 270 280 290 300
QITKIDKIKT ALIEGARVYT ELRKMGMGIE FVDIGGGLGV DYDGSKSSYF
310 320 330 340 350
SSVNYSVEEY ANDVIYQIKN ICDDAGVECP NIISESGRAT VAHYSVLVTN
360 370 380 390 400
VLNTNTQRLT PDFEEELAAA EKLAPTVKKL VDIHKSIDRY SLREDYHDTV
410 420 430 440 450
QLIQEAVSLF NLGYLTLNER AMAEWLYGKI IKKINSIVEK IKPIPEELQN
460 470 480 490 500
FQLALRQTYF ANFSLFQSIP DSWAIDQLFP IVPIQRLNQK PDVIASIADI
510 520 530 540 550
TCDSDGEITS FVGENGRTKF LPLHKIRKDE DYYIGFFLIG AYQEILGDMH
560 570 580 590 600
NLFGDTNAVH ITFNKKTGYM IDTVINGDAC WESLKYVQYK GPEILKRVRE
610 620 630
HLEKGVAQRK VSIEESSHFI ELLDRTLLGY TYLGE
Length:635
Mass (Da):71,555
Last modified:March 24, 2009 - v1
Checksum:iF80B33DABDF7CAD7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001390 Genomic DNA. Translation: ACM20036.1.
RefSeqiYP_002537137.1. NC_011979.1.

Genome annotation databases

EnsemblBacteriaiACM20036; ACM20036; Geob_1678.
GeneIDi7362608.
KEGGigeo:Geob_1678.
PATRICi22009921. VBIGeoSp137169_1730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001390 Genomic DNA. Translation: ACM20036.1 .
RefSeqi YP_002537137.1. NC_011979.1.

3D structure databases

ProteinModelPortali B9M6H6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316067.Geob_1678.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM20036 ; ACM20036 ; Geob_1678 .
GeneIDi 7362608.
KEGGi geo:Geob_1678.
PATRICi 22009921. VBIGeoSp137169_1730.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci GSP316067:GHSV-1696-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22248 / JCM 15807 / FRC-32.

Entry informationi

Entry nameiSPEA_GEODF
AccessioniPrimary (citable) accession number: B9M6H6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3