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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciGDAL316067:G1GUR-1575-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Geob_1561
OrganismiGeobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Taxonomic identifieri316067 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
Proteomesi
  • UP000007721 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001494721 – 437Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST437

Proteomic databases

PRIDEiB9M5T8

Interactioni

Protein-protein interaction databases

STRINGi316067.Geob_1561

Structurei

3D structure databases

ProteinModelPortaliB9M5T8
SMRiB9M5T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI Bacteria
COG1206 LUCA
HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP
OrthoDBiPOG091H00B3

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR020595 MnmG-rel_CS
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit
PROSITEiView protein in PROSITE
PS01281 GIDA_2, 1 hit

Sequencei

Sequence statusi: Complete.

B9M5T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNNKIKIIG GGLAGCEAAW QAAERGVAVK LHEMKPERYS PAHHLPGLAE
60 70 80 90 100
LVCSNSLRGE SLDNAVGLLK EELKRSGSLF IAAALATRVP AGGALAVDRQ
110 120 130 140 150
LFSDYITEKI TNHPLIEVVY GEVAQIPEEG IVIVASGPLT SDRLAASIAT
160 170 180 190 200
HTGNYLYFYD AIAPIVTADS IDFGKAFRAS RYGKGDGDDY LNCPMDETTY
210 220 230 240 250
KAFVAALLGG DKVAAKDFEK VVHFEGCMPI EEMAERGPET LRFGPMKPVG
260 270 280 290 300
LPDPRTGVEP YAVVQLRQEN RDGTLFNLVG FQTKLTYSEQ KRIFSLIPGL
310 320 330 340 350
EHADFVRLGS MHRNTFINAP QLLLPTFQLK NTPRILFAGQ ITGVEGYVES
360 370 380 390 400
AGSGFMAGIN VARLAKGGAL TVPPPTTALG ALVHHITSVD TKHFQPMNVN
410 420 430
YGLFPELGGK VKKKDKRARL AERALTDLTE WQGMVQD
Length:437
Mass (Da):47,378
Last modified:March 24, 2009 - v1
Checksum:i19B65907E99CD0DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001390 Genomic DNA Translation: ACM19919.1
RefSeqiWP_012646648.1, NC_011979.1

Genome annotation databases

EnsemblBacteriaiACM19919; ACM19919; Geob_1561
KEGGigeo:Geob_1561

Similar proteinsi

Entry informationi

Entry nameiTRMFO_GEODF
AccessioniPrimary (citable) accession number: B9M5T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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