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B9M4S5 (B9M4S5_GEOSF) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Carbamoyl-phosphate synthase small chain HAMAP-Rule MF_01209
EC=6.3.5.5 HAMAP-Rule MF_01209
Alternative name(s):
Carbamoyl-phosphate synthetase glutamine chain HAMAP-Rule MF_01209
Gene names
Name:carA HAMAP-Rule MF_01209
Ordered Locus Names:Geob_3266 EMBL ACM21609.1
OrganismGeobacter sp. (strain FRC-32) [Complete proteome] [HAMAP] EMBL ACM21609.1
Taxonomic identifier316067 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter ›

Protein attributes

Sequence length373 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 ATP + L-glutamine + HCO3- + H2O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate. HAMAP-Rule MF_01209

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1. HAMAP-Rule MF_01209

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3. HAMAP-Rule MF_01209 SAAS SAAS006274

Subunit structure

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate By similarity. HAMAP-Rule MF_01209

Sequence similarities

Belongs to the CarA family. HAMAP-Rule MF_01209

Contains 1 glutamine amidotransferase type-1 domain. HAMAP-Rule MF_01209

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain189 – 373185Glutamine amidotransferase type-1 By similarity HAMAP-Rule MF_01209
Region1 – 185185CPSase By similarity HAMAP-Rule MF_01209

Sites

Active site2641Nucleophile By similarity HAMAP-Rule MF_01209
Active site3481 By similarity HAMAP-Rule MF_01209
Active site3501 By similarity HAMAP-Rule MF_01209

Sequences

Sequence LengthMass (Da)Tools
B9M4S5 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 376F22053947BF63

FASTA37340,816
        10         20         30         40         50         60 
MKAVLALADG RIFKGRSFGA SGEATGEVVF NTAMTGYQEV LTDPSYKGQM VTMTYTQIGN 

        70         80         90        100        110        120 
TGINGEDIES KQLYLSGFIV KEYHDCHSNW RATMSLDAYL KENGIVGIQG LDTRALTRHL 

       130        140        150        160        170        180 
RDNGAQNGII STVDFDPESL VKKARAIPSM AGLDLASGVS TDKPYHWTQG LWDLEGGYPE 

       190        200        210        220        230        240 
VDAKNLKYKV VAYDFGIKYN ILRCLVDAGC DVTVVPATFP AEEALAMNPD GIFLSNGPGD 

       250        260        270        280        290        300 
PEPLVKVQEE IRKFIGKKPI FGICLGHQLL GLALGGKTIK LKFGNHGSNL PVMDMETRKV 

       310        320        330        340        350        360 
EITAQNHGFA VDLESLGDVA CLGHENLNDQ TVEGIRHCTL PIYSVQHHPE ASPGPHDSHY 

       370 
LFARFVELME KNR

« Hide

References

[1]"Complete sequence of Geobacter sp. FRC-32."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kostka J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FRC-32 EMBL ACM21609.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001390 Genomic DNA. Translation: ACM21609.1.
RefSeqYP_002538710.1. NC_011979.1.

3D structure databases

ProteinModelPortalB9M4S5.
ModBaseSearch...

Protein-protein interaction databases

STRING316067.Geob_3266.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM21609; ACM21609; Geob_3266.
GeneID7362751.
KEGGgeo:Geob_3266.
PATRIC22013247. VBIGeoSp137169_3368.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0505.
HOGENOMHOG000038087.
KOK01956.
OMARDSHYLF.
ProtClustDBPRK12564.

Enzyme and pathway databases

BioCycGSP316067:GHSV-3311-MONOMER.
UniPathwayUPA00068; UER00171.
UPA00070; UER00115.

Family and domain databases

Gene3D3.50.30.20. 1 hit.
HAMAPMF_01209. CPSase_S_chain.
InterProIPR006274. CarbamoylP_synth_ssu.
IPR002474. CarbamoylP_synth_ssu_N.
IPR017926. GATASE_1.
[Graphical view]
PfamPF00988. CPSase_sm_chain. 1 hit.
PF00117. GATase. 1 hit.
[Graphical view]
SMARTSM01097. CPSase_sm_chain. 1 hit.
[Graphical view]
SUPFAMSSF52021. CP_synthsmall. 1 hit.
TIGRFAMsTIGR01368. CPSaseIIsmall. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB9M4S5_GEOSF
AccessionPrimary (citable) accession number: B9M4S5
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info