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B9M4Q6

- PUR9_GEODF

UniProt

B9M4Q6 - PUR9_GEODF

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, Geob_1422
Organism
Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciGSP316067:GHSV-1438-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:Geob_1422
OrganismiGeobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Taxonomic identifieri316067 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000007721: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000122961Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi316067.Geob_1422.

Structurei

3D structure databases

ProteinModelPortaliB9M4Q6.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230372.
KOiK00602.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

B9M4Q6-1 [UniParc]FASTAAdd to Basket

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MAKISRALIS VSDKTGIVDF SKELAGYGVE ILSTGGTAKL LREAGLAVKD    50
VSEFTGFPEM LDGRVKTLHP KVHGGLLGMR GNSEHVATMK AHGIEPIDMV 100
VVNLYPFEAT VAKPDCSLED AIENIDIGGP TMLRSAAKNN ADVTVLVDHN 150
DYRKVLDEMK QSGGAVSSAT NFGLAVKVYQ HTAAYDGAIS NWLGARTGEG 200
VAEYPDTLTF QFKKAQGMRY GENPHQSAAF YVERDVKEAS IATALQLQGK 250
ELSYNNIGDT DAALECIKQF NEGPACVIVK HANPCGVAIG ANLLDAYDRA 300
YKTDPESAFG GIIAFNGELD EAAAKAIVDR QFVEVIIAPK VSAKASEIVA 350
AKKNVRLLQC GQWQAESLAR LDMKRVNGGL LVQQTDLSLH GELKVVTKRQ 400
PTEKEMIDLL FTWRVAKFVK SNAIVYGKDG MTIGVGAGQM SRVNSARIAA 450
IKAEHAGLQV AGAVMASDAF FPFRDGIDNA AQVGITAVIQ PGGSMRDEEV 500
IAAADEHGMA MVFTSMRHFR H 521
Length:521
Mass (Da):55,890
Last modified:March 24, 2009 - v1
Checksum:i038B1F2F406D120D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001390 Genomic DNA. Translation: ACM19782.1.
RefSeqiYP_002536883.1. NC_011979.1.

Genome annotation databases

EnsemblBacteriaiACM19782; ACM19782; Geob_1422.
GeneIDi7362103.
KEGGigeo:Geob_1422.
PATRICi22009381. VBIGeoSp137169_1461.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001390 Genomic DNA. Translation: ACM19782.1 .
RefSeqi YP_002536883.1. NC_011979.1.

3D structure databases

ProteinModelPortali B9M4Q6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 316067.Geob_1422.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM19782 ; ACM19782 ; Geob_1422 .
GeneIDi 7362103.
KEGGi geo:Geob_1422.
PATRICi 22009381. VBIGeoSp137169_1461.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230372.
KOi K00602.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci GSP316067:GHSV-1438-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 22248 / JCM 15807 / FRC-32.

Entry informationi

Entry nameiPUR9_GEODF
AccessioniPrimary (citable) accession number: B9M4Q6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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