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B9M3X6

- GCSPA_GEODF

UniProt

B9M3X6 - GCSPA_GEODF

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciGSP316067:GHSV-1274-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Geob_1259
    OrganismiGeobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
    Taxonomic identifieri316067 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000007721: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000147986Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi316067.Geob_1259.

    Structurei

    3D structure databases

    ProteinModelPortaliB9M3X6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B9M3X6-1 [UniParc]FASTAAdd to Basket

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    MSYCPNTPED IREMLAAIGK GSVEELFEPI HHTLRAKSFN LPAGISEQEL    50
    LVKMQELAAC DRHLINFIGG GYYDHHIPAV VDHLSGRAEF YTAYTPYQPE 100
    CSQGTLQALF EYQTAICRLT GMEVSNASLY DGGTALAEAA MMALRITGRN 150
    RVVIDASVNP FARQIVATYL KNIGVEMVEI PTSSGSADRS ALTEALTGDV 200
    AAVMVQNPNF FGSIEDLTAI SQAAHAKGAL LVTSVYPISL GLIKSPGEMG 250
    ADIVVGDGQS LGNPLAFGGP SFGFIATTKK YIRNLPGRII GETIDKEGRR 300
    GFVLTLQARE QHIKRHKATS NICSNQSLCA LRGLIFLASV GKEGMVELAN 350
    LNRDKAEYAK ERLGSIRGVR VLNRGATFNE FTLELPKDAA DVVRTLMEKG 400
    IAAGVPLGEY YAGMANCMVV TVTEKRSRGE IEALAEALEA SL 442
    Length:442
    Mass (Da):47,608
    Last modified:March 24, 2009 - v1
    Checksum:i619DCD2C3A8CD2D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001390 Genomic DNA. Translation: ACM19619.1.
    RefSeqiYP_002536720.1. NC_011979.1.

    Genome annotation databases

    EnsemblBacteriaiACM19619; ACM19619; Geob_1259.
    GeneIDi7363082.
    KEGGigeo:Geob_1259.
    PATRICi22009036. VBIGeoSp137169_1290.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001390 Genomic DNA. Translation: ACM19619.1 .
    RefSeqi YP_002536720.1. NC_011979.1.

    3D structure databases

    ProteinModelPortali B9M3X6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316067.Geob_1259.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM19619 ; ACM19619 ; Geob_1259 .
    GeneIDi 7363082.
    KEGGi geo:Geob_1259.
    PATRICi 22009036. VBIGeoSp137169_1290.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci GSP316067:GHSV-1274-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 22248 / JCM 15807 / FRC-32.

    Entry informationi

    Entry nameiGCSPA_GEODF
    AccessioniPrimary (citable) accession number: B9M3X6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3