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B9M3X6 (GCSPA_GEODF) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Geob_1259
OrganismGeobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32) [Complete proteome] [HAMAP]
Taxonomic identifier316067 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000147986

Sequences

Sequence LengthMass (Da)Tools
B9M3X6 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 619DCD2C3A8CD2D8

FASTA44247,608
        10         20         30         40         50         60 
MSYCPNTPED IREMLAAIGK GSVEELFEPI HHTLRAKSFN LPAGISEQEL LVKMQELAAC 

        70         80         90        100        110        120 
DRHLINFIGG GYYDHHIPAV VDHLSGRAEF YTAYTPYQPE CSQGTLQALF EYQTAICRLT 

       130        140        150        160        170        180 
GMEVSNASLY DGGTALAEAA MMALRITGRN RVVIDASVNP FARQIVATYL KNIGVEMVEI 

       190        200        210        220        230        240 
PTSSGSADRS ALTEALTGDV AAVMVQNPNF FGSIEDLTAI SQAAHAKGAL LVTSVYPISL 

       250        260        270        280        290        300 
GLIKSPGEMG ADIVVGDGQS LGNPLAFGGP SFGFIATTKK YIRNLPGRII GETIDKEGRR 

       310        320        330        340        350        360 
GFVLTLQARE QHIKRHKATS NICSNQSLCA LRGLIFLASV GKEGMVELAN LNRDKAEYAK 

       370        380        390        400        410        420 
ERLGSIRGVR VLNRGATFNE FTLELPKDAA DVVRTLMEKG IAAGVPLGEY YAGMANCMVV 

       430        440 
TVTEKRSRGE IEALAEALEA SL 

« Hide

References

[1]"Complete sequence of Geobacter sp. FRC-32."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kostka J., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 22248 / JCM 15807 / FRC-32.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001390 Genomic DNA. Translation: ACM19619.1.
RefSeqYP_002536720.1. NC_011979.1.

3D structure databases

ProteinModelPortalB9M3X6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING316067.Geob_1259.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM19619; ACM19619; Geob_1259.
GeneID7363082.
KEGGgeo:Geob_1259.
PATRIC22009036. VBIGeoSp137169_1290.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycGSP316067:GHSV-1274-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_GEODF
AccessionPrimary (citable) accession number: B9M3X6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families