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B9M1G5

- PNP_GEODF

UniProt

B9M1G5 - PNP_GEODF

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Geobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi483 – 4831MagnesiumUniRule annotation
    Metal bindingi489 – 4891MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciGSP316067:GHSV-2728-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Geob_2697
    OrganismiGeobacter daltonii (strain DSM 22248 / JCM 15807 / FRC-32)
    Taxonomic identifieri316067 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
    ProteomesiUP000007721: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 696696Polyribonucleotide nucleotidyltransferasePRO_0000381900Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi316067.Geob_2697.

    Structurei

    3D structure databases

    ProteinModelPortaliB9M1G5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini550 – 60960KHUniRule annotationAdd
    BLAST
    Domaini619 – 68769S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218327.
    KOiK00962.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9M1G5-1 [UniParc]FASTAAdd to Basket

    « Hide

    METKVQVECG GRTITIETGK MAKQASGAVV VSSGDTRVLV TAVATKTAKE    50
    GQDFFPLTVN YQEKAYAGGK IPGGFFKREA RPSDNETLTC RLIDRPIRPL 100
    FPDNFLNDTQ IMATVISADK DNDPGILSMV GASAALMVSD IPFQGPIAGV 150
    KVGRIDGRFV ANPGFEEMEK SDIEIVVAAS KDAIIMVEGS AAEVSEEDML 200
    EAIFFGHAAI QGLLAAQVEL AEKAGVAKRE VLPPVVNEAL KAKVKELAYS 250
    RMKEAVRIKS KVERHNTIDT ITGEVLTALA EEFEGAAKEI KGFLGDFEYD 300
    LVREHIIKDG ERIDGRDTKT IRQITTEVGL LPRAHGSALF TRGETQALVV 350
    ATLGTSIDEQ RIDSLFGESK KRFLLHYNFP PFSVGETSFR LAPGRREIGH 400
    GMLAERALAR VVPKHESFPY TIRIVSDILE SNGSSSMASV CGGSMSMMDA 450
    GIPIKAPVAG IAMGLIKEGD DFAILSDILG DEDHLGDMDF KVAGTSTGVT 500
    ALQMDIKIGG VTREIMGVAL KQAHEGRLHI LSKMAETIGT SKAELSTFAP 550
    RITTIYVKTD KIRDVIGSGG KNIRGITEAT GVTIDIDDTG KINIASTDKA 600
    ACDMAIKMIR DLTAEAEEGK LYMGLVKKVM EFGAFVEIFP GTDGLVHISE 650
    LDTERVKNVT DVLKEGDKVL VKCIGIDKQG KIKLSRKEAL GASLPE 696
    Length:696
    Mass (Da):74,895
    Last modified:March 24, 2009 - v1
    Checksum:i70EE0A2F8F3FC5F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001390 Genomic DNA. Translation: ACM21047.1.
    RefSeqiYP_002538148.1. NC_011979.1.

    Genome annotation databases

    EnsemblBacteriaiACM21047; ACM21047; Geob_2697.
    GeneIDi7361352.
    KEGGigeo:Geob_2697.
    PATRICi22012063. VBIGeoSp137169_2789.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001390 Genomic DNA. Translation: ACM21047.1 .
    RefSeqi YP_002538148.1. NC_011979.1.

    3D structure databases

    ProteinModelPortali B9M1G5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 316067.Geob_2697.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM21047 ; ACM21047 ; Geob_2697 .
    GeneIDi 7361352.
    KEGGi geo:Geob_2697.
    PATRICi 22012063. VBIGeoSp137169_2789.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218327.
    KOi K00962.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci GSP316067:GHSV-2728-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF00013. KH_1. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 22248 / JCM 15807 / FRC-32.

    Entry informationi

    Entry nameiPNP_GEODF
    AccessioniPrimary (citable) accession number: B9M1G5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3