B9LZL6 (GSA_GEOSF) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	Geob_0461

Organism

Geobacter sp. (strain FRC-32) [Complete proteome] [HAMAP]

Taxonomic identifier

316067 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfuromonadales › Geobacteraceae › Geobacter › Geobacter daltonii

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375		PRO_1000201021
Amino acid modifications
	Modified residue	267	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9LZL6 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: AB1173EDEA194BBE	FASTA	427	45,280
	10 20 30 40 50 60 MNFSRSADLF KQAQNSIPGG VNSPVRAFKS VGRDPLFIKK ASGCKIEDVD GNQFIDFVGS 70 80 90 100 110 120 WGPMILGHCH PQVASAVKAA VDSGCSFGAP TELEITLAEM VINAVPSIEM VRMVSSGTEA 130 140 150 160 170 180 TMSAIRLARG YTGRDKILKF SGCYHGHSDS LLVKAGSGAA TFGVPDSPGV PQDFARHTLT 190 200 210 220 230 240 ADYNSLESVR TLIAENKGQV ACIIVEPVAG NMGTVPPREG FLEGLRTLCT QEGIVLIFDE 250 260 270 280 290 300 VMSGFRVAYG GAQEVYGVTP DMTTLGKIIG GGLPVGAFGG KKEIMTLLSP SGGVYQAGTL 310 320 330 340 350 360 SGNPLAMTAG IETLKLLQAE GFYRNLEEKS SYVAAGIARA AEKAGFPIYS ARVGSMFCAF 370 380 390 400 410 420 FSKDPVYDWT TAAKCDTEAF AKYFRLMLGE GIYLAPSQYE TAFVSIAHAT EDLDRTIAAA EKSFRAL

References

[1]

"Complete sequence of Geobacter sp. FRC-32." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Saunders E., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Kostka J., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: FRC-32.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001390 Genomic DNA. Translation: ACM18830.1.
RefSeq	YP_002535931.1. NC_011979.1.
3D structure databases
ProteinModelPortal	B9LZL6.
ModBase	Search...
Protein-protein interaction databases
STRING	316067.Geob_0461.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACM18830; ACM18830; Geob_0461.
GeneID	7361949.
KEGG	geo:Geob_0461.
PATRIC	22007395. VBIGeoSp137169_0478.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	NANIPFF.
ProtClustDB	PRK00062.
Enzyme and pathway databases
BioCyc	GSP316067:GHSV-467-MONOMER.
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_GEOSF

Accession

Primary (citable) accession number: B9LZL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program