B9LUD2 (AROA_HALLT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable 3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	Hlac_0687

Organism

Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) [Complete proteome] [HAMAP]

Taxonomic identifier

416348 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halorubrum

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Probable 3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000124689

Sequences

	Sequence		Length	Mass (Da)
	B9LUD2 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 44A4F96334A83DC5	FASTA	453	46,141
	10 20 30 40 50 60 MDVNVTSSTV RGTTRAPPSK SYTHRALLAA GYSDGATVRS PLVSADTKAT ARAVTAFGGA 70 80 90 100 110 120 VEPESGERFD DADALVVDGF DGRPAVPDDV IDCANSGTTM RLVTAAAALA DGTTVLTGDE 130 140 150 160 170 180 SLRSRPQGPL LEALGDLGVR AESTRGNGQA PLVVSGPLAG GEVAIPGNVS SQYVTALLMA 190 200 210 220 230 240 GAVTEEGVEI DLTTPLKSAP YVDITLELLD DFGIEATPVG DGGDALDGAA GAAGFVVDGG 250 260 270 280 290 300 QSYAPAGGSY TVPGDFSSIS YLVAAGAVAA EPGEPVRIEG AVPSAQGDSA IVEIVERMGA 310 320 330 340 350 360 DIEWDREAGV ITVRRSELSG VEVDVGDTPD LLPTIAALGA VADGDTRIMN CEHVRYKETD 370 380 390 400 410 420 RVSAMAEELE KLGAKTTEEP DTLTVHGSES DLRGASVDGR ADHRIVMALA VAALVAEGTT 430 440 450 TIRGGEHVDV SFPNFFDAMA DLGIAVERDG AGE

References

[1]

"Complete sequence of chromosome1 of Halorubrum lacusprofundi ATCC 49239." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. , Anderson I., DasSarma S., Cavicchioli R., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001365 Genomic DNA. Translation: ACM56289.1.
RefSeq	YP_002565359.1. NC_012029.1.
3D structure databases
ProteinModelPortal	B9LUD2.
ModBase	Search...
Protein-protein interaction databases
STRING	B9LUD2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7401822.
GenomeReviews	Gene locus Hlac_0687 in contig CP001365_GR.
KEGG	hla:Hlac_0687.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RLRIKEC.
ProtClustDB	PRK02427.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. 1 hit. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_HALLT

Accession

Primary (citable) accession number: B9LUD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	November 16, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program