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Protein

IMP cyclohydrolase

Gene

purO

Organism
Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.UniRule annotation

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purOUniRule annotation
Ordered Locus Names:Hlac_2704
OrganismiHalorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Taxonomic identifieri416348 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHalorubraceaeHalorubrum
Proteomesi
  • UP000000740 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001930621 – 202IMP cyclohydrolaseAdd BLAST202

Interactioni

Protein-protein interaction databases

STRINGi416348.Hlac_2704

Structurei

3D structure databases

ProteinModelPortaliB9LU81
SMRiB9LU81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04727 Archaea
COG3363 LUCA
HOGENOMiHOG000015497
KOiK11176
OMAiSHVDPIA
OrthoDBiPOG093Z0CY5

Family and domain databases

Gene3Di3.60.20.20, 1 hit
HAMAPiMF_00705 IMP_cyclohydrol, 1 hit
InterProiView protein in InterPro
IPR010191 IMP_cyclohydrolase
IPR020600 IMP_cyclohydrolase-like
IPR036795 IMP_cyclohydrolase-like_sf
PfamiView protein in Pfam
PF07826 IMP_cyclohyd, 1 hit
PIRSFiPIRSF004866 IMP_cclhdr_arch, 1 hit
SUPFAMiSSF75569 SSF75569, 1 hit
TIGRFAMsiTIGR01922 purO_arch, 1 hit

Sequencei

Sequence statusi: Complete.

B9LU81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVGRFVVVA PGIGAYRVSS RSFPNRRVTD RDGRLTVGPT PDAPETDNPY
60 70 80 90 100
VSYNCARAVR TPTDEPLAVV GNGSHVDPIA EKLELGYPAR DALATPLLAL
110 120 130 140 150
DFEKDDYDTP RIAGVVGAET ATIGVVRRDG LVVEAVDEPT IVATYETDSP
160 170 180 190 200
EPYALAAADA ETPDAAAAAT EVLGADFEHP VCAAGATVDA DGATLAFDND

AE
Length:202
Mass (Da):21,121
Last modified:March 24, 2009 - v1
Checksum:iFE92CBCABC2370B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001365 Genomic DNA Translation: ACM58275.1
RefSeqiWP_015911385.1, NC_012029.1

Genome annotation databases

EnsemblBacteriaiACM58275; ACM58275; Hlac_2704
GeneIDi7401315
KEGGihla:Hlac_2704

Similar proteinsi

Entry informationi

Entry nameiPURO_HALLT
AccessioniPrimary (citable) accession number: B9LU81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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