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Protein

IMP cyclohydrolase

Gene

purO

Organism
Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.UniRule annotation

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciHLAC416348:GIWW-2762-MONOMER.
UniPathwayiUPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purOUniRule annotation
Ordered Locus Names:Hlac_2704
OrganismiHalorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Taxonomic identifieri416348 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHalorubrum
Proteomesi
  • UP000000740 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 202202IMP cyclohydrolasePRO_1000193062Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416348.Hlac_2704.

Structurei

3D structure databases

ProteinModelPortaliB9LU81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04727. Archaea.
COG3363. LUCA.
HOGENOMiHOG000015497.
KOiK11176.
OMAiSYNCARA.

Family and domain databases

Gene3Di3.60.20.20. 1 hit.
HAMAPiMF_00705. IMP_cyclohydrol.
InterProiIPR010191. IMP_cyclohydrolase.
IPR020600. IMP_cyclohydrolase-like.
[Graphical view]
PfamiPF07826. IMP_cyclohyd. 1 hit.
[Graphical view]
PIRSFiPIRSF004866. IMP_cclhdr_arch. 1 hit.
SUPFAMiSSF75569. SSF75569. 1 hit.
TIGRFAMsiTIGR01922. purO_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

B9LU81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYVGRFVVVA PGIGAYRVSS RSFPNRRVTD RDGRLTVGPT PDAPETDNPY
60 70 80 90 100
VSYNCARAVR TPTDEPLAVV GNGSHVDPIA EKLELGYPAR DALATPLLAL
110 120 130 140 150
DFEKDDYDTP RIAGVVGAET ATIGVVRRDG LVVEAVDEPT IVATYETDSP
160 170 180 190 200
EPYALAAADA ETPDAAAAAT EVLGADFEHP VCAAGATVDA DGATLAFDND

AE
Length:202
Mass (Da):21,121
Last modified:March 24, 2009 - v1
Checksum:iFE92CBCABC2370B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001365 Genomic DNA. Translation: ACM58275.1.
RefSeqiWP_015911385.1. NC_012029.1.

Genome annotation databases

EnsemblBacteriaiACM58275; ACM58275; Hlac_2704.
GeneIDi7401315.
KEGGihla:Hlac_2704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001365 Genomic DNA. Translation: ACM58275.1.
RefSeqiWP_015911385.1. NC_012029.1.

3D structure databases

ProteinModelPortaliB9LU81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi416348.Hlac_2704.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM58275; ACM58275; Hlac_2704.
GeneIDi7401315.
KEGGihla:Hlac_2704.

Phylogenomic databases

eggNOGiarCOG04727. Archaea.
COG3363. LUCA.
HOGENOMiHOG000015497.
KOiK11176.
OMAiSYNCARA.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00135.
BioCyciHLAC416348:GIWW-2762-MONOMER.

Family and domain databases

Gene3Di3.60.20.20. 1 hit.
HAMAPiMF_00705. IMP_cyclohydrol.
InterProiIPR010191. IMP_cyclohydrolase.
IPR020600. IMP_cyclohydrolase-like.
[Graphical view]
PfamiPF07826. IMP_cyclohyd. 1 hit.
[Graphical view]
PIRSFiPIRSF004866. IMP_cclhdr_arch. 1 hit.
SUPFAMiSSF75569. SSF75569. 1 hit.
TIGRFAMsiTIGR01922. purO_arch. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome1 of Halorubrum lacusprofundi ATCC 49239."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N.
    , Anderson I., DasSarma S., Cavicchioli R., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34.

Entry informationi

Entry nameiPURO_HALLT
AccessioniPrimary (citable) accession number: B9LU81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: December 9, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.