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B9LTZ6 (B9LTZ6_HALLT) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate synthase HAMAP-Rule MF_00005
EC=6.3.4.5 HAMAP-Rule MF_00005
Alternative name(s):
Citrulline--aspartate ligase HAMAP-Rule MF_00005
Gene names
Name:argG HAMAP-Rule MF_00005
Ordered Locus Names:Hlac_2619 EMBL ACM58190.1
OrganismHalorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) [Complete proteome] [HAMAP] EMBL ACM58190.1
Taxonomic identifier416348 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halorubrum ›

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00005

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00005.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily. HAMAP-Rule MF_00005

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding7 – 159ATP By similarity HAMAP-Rule MF_00005

Sites

Binding site841Citrulline By similarity HAMAP-Rule MF_00005
Binding site1141ATP; via amide nitrogen By similarity HAMAP-Rule MF_00005
Binding site1161Aspartate By similarity HAMAP-Rule MF_00005
Binding site1201Aspartate By similarity HAMAP-Rule MF_00005
Binding site1201Citrulline By similarity HAMAP-Rule MF_00005
Binding site1211Aspartate By similarity HAMAP-Rule MF_00005
Binding site1241Citrulline By similarity HAMAP-Rule MF_00005
Binding site1701Citrulline By similarity HAMAP-Rule MF_00005
Binding site2511Citrulline By similarity HAMAP-Rule MF_00005
Binding site2631Citrulline By similarity HAMAP-Rule MF_00005

Sequences

Sequence LengthMass (Da)Tools
B9LTZ6 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 02A37D364493C342

FASTA41244,490
        10         20         30         40         50         60 
MATVALAFSG GLDTTVCVPL LKEEYGYDEV IGVNVDVGQP TEEFDEAEET ADALGLDLHV 

        70         80         90        100        110        120 
VDAKEEFADL CYDAVKTNAT YQGYPLGTAL ARPVIAEAIL GVAEEQGCDA IAHGCTGKGN 

       130        140        150        160        170        180 
DQLRFEAVWR GSDLEVIAPV RELGLTREWE IDYAAEKDLP VEAGDGGVWS IDENIWSRAV 

       190        200        210        220        230        240 
EGGKLEDPSY EPPEDIYEWT AGPEGETTIE VTFEEGVPVA IDGEAMDPVP LIQYLNKYAG 

       250        260        270        280        290        300 
GYGIGRTDVM EDRMLGLKVR ENYEHPAATV LLTAHQALED LVLTKNERSF KKGIEQEWSE 

       310        320        330        340        350        360 
KAYQGLVFAP VVDALDAFVD ETQDVVTGTA TVKVSGGNCR VVARDSEYAV YSEEMASFNT 

       370        380        390        400        410 
EDVAGIAQED ATGVAKYHGL QERLANDVKA GVEKPELATD GSGAADEIDD EN

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References

[1]"Complete sequence of chromosome1 of Halorubrum lacusprofundi ATCC 49239."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. expand/collapse author list , Anderson I., DasSarma S., Cavicchioli R., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001365 Genomic DNA. Translation: ACM58190.1.
RefSeqYP_002567260.1. NC_012029.1.

3D structure databases

ProteinModelPortalB9LTZ6.
ModBaseSearch...

Protein-protein interaction databases

STRING416348.Hlac_2619.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM58190; ACM58190; Hlac_2619.
GeneID7399845.
KEGGhla:Hlac_2619.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230093.
KOK01940.
OMANDQFRFE.
ProtClustDBPRK13820.

Enzyme and pathway databases

BioCycHLAC416348:GIWW-2674-MONOMER.
UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR11587. PTHR11587. 1 hit.
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB9LTZ6_HALLT
AccessionPrimary (citable) accession number: B9LTZ6
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: May 29, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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