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B9LTZ6

- B9LTZ6_HALLT

UniProt

B9LTZ6 - B9LTZ6_HALLT

Protein

Argininosuccinate synthase

Gene

argG

Organism
Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841CitrullineUniRule annotation
    Binding sitei114 – 1141ATP; via amide nitrogenUniRule annotation
    Binding sitei116 – 1161AspartateUniRule annotation
    Binding sitei120 – 1201AspartateUniRule annotation
    Binding sitei120 – 1201CitrullineUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei124 – 1241CitrullineUniRule annotation
    Binding sitei170 – 1701CitrullineUniRule annotation
    Binding sitei251 – 2511CitrullineUniRule annotation
    Binding sitei263 – 2631CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 159ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHLAC416348:GIWW-2674-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Hlac_2619Imported
    OrganismiHalorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)Imported
    Taxonomic identifieri416348 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalorubrum
    ProteomesiUP000000740: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi416348.Hlac_2619.

    Structurei

    3D structure databases

    ProteinModelPortaliB9LTZ6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiAPPEEAY.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9LTZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATVALAFSG GLDTTVCVPL LKEEYGYDEV IGVNVDVGQP TEEFDEAEET    50
    ADALGLDLHV VDAKEEFADL CYDAVKTNAT YQGYPLGTAL ARPVIAEAIL 100
    GVAEEQGCDA IAHGCTGKGN DQLRFEAVWR GSDLEVIAPV RELGLTREWE 150
    IDYAAEKDLP VEAGDGGVWS IDENIWSRAV EGGKLEDPSY EPPEDIYEWT 200
    AGPEGETTIE VTFEEGVPVA IDGEAMDPVP LIQYLNKYAG GYGIGRTDVM 250
    EDRMLGLKVR ENYEHPAATV LLTAHQALED LVLTKNERSF KKGIEQEWSE 300
    KAYQGLVFAP VVDALDAFVD ETQDVVTGTA TVKVSGGNCR VVARDSEYAV 350
    YSEEMASFNT EDVAGIAQED ATGVAKYHGL QERLANDVKA GVEKPELATD 400
    GSGAADEIDD EN 412
    Length:412
    Mass (Da):44,490
    Last modified:March 24, 2009 - v1
    Checksum:i02A37D364493C342
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001365 Genomic DNA. Translation: ACM58190.1.
    RefSeqiYP_002567260.1. NC_012029.1.

    Genome annotation databases

    EnsemblBacteriaiACM58190; ACM58190; Hlac_2619.
    GeneIDi7399845.
    KEGGihla:Hlac_2619.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001365 Genomic DNA. Translation: ACM58190.1 .
    RefSeqi YP_002567260.1. NC_012029.1.

    3D structure databases

    ProteinModelPortali B9LTZ6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 416348.Hlac_2619.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM58190 ; ACM58190 ; Hlac_2619 .
    GeneIDi 7399845.
    KEGGi hla:Hlac_2619.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi APPEEAY.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci HLAC416348:GIWW-2674-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome1 of Halorubrum lacusprofundi ATCC 49239."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N.
      , Anderson I., DasSarma S., Cavicchioli R., Richardson P.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34Imported.

    Entry informationi

    Entry nameiB9LTZ6_HALLT
    AccessioniPrimary (citable) accession number: B9LTZ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 24, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3