SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B9LPF8

- NADK_HALLT

UniProt

B9LPF8 - NADK_HALLT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

NAD kinase

Gene
nadK, Hlac_1661
Organism
Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Proton acceptor By similarity
Binding sitei168 – 1681NAD By similarity
Binding sitei170 – 1701NAD By similarity
Binding sitei205 – 2051NAD; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 672NAD By similarity
Nucleotide bindingi138 – 1392NAD By similarity
Nucleotide bindingi181 – 1866NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHLAC416348:GIWW-1699-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:Hlac_1661
OrganismiHalorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Taxonomic identifieri416348 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalorubrum
ProteomesiUP000000740: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275NAD kinaseUniRule annotationPRO_1000133574Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416348.Hlac_1661.

Structurei

3D structure databases

ProteinModelPortaliB9LPF8.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiNLSERGP.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B9LPF8-1 [UniParc]FASTAAdd to Basket

« Hide

MQVGIVARKG SERAVAVADE LRDAVAGAGA SVWLDAETAD ALGEPAAGRE    50
VDALADCDLA VAVGGDGTFL FVARNAGDTP IVGVNLGEVG FLNAVPPEAA 100
EEAVVSEVEA FDRGEMNVRE APRLAARTDE WTSVPAANEV VIQGARRGPG 150
AGIDYEVRVD GSRYAGGHAD GVLVATPTGS TAYNLSEGGP LVHPAVSGLV 200
VNEMVAEEGM PPIVVDADAT VTVAVEGVDE VVVASDGRNV TTLPAPTEVT 250
VERTTPPMRI AGPPSDFFAA LEKLS 275
Length:275
Mass (Da):28,022
Last modified:March 24, 2009 - v1
Checksum:i3D67FE31021935F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001365 Genomic DNA. Translation: ACM57246.1.
RefSeqiWP_015910384.1. NC_012029.1.
YP_002566316.1. NC_012029.1.

Genome annotation databases

EnsemblBacteriaiACM57246; ACM57246; Hlac_1661.
GeneIDi7399612.
KEGGihla:Hlac_1661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001365 Genomic DNA. Translation: ACM57246.1 .
RefSeqi WP_015910384.1. NC_012029.1.
YP_002566316.1. NC_012029.1.

3D structure databases

ProteinModelPortali B9LPF8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416348.Hlac_1661.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM57246 ; ACM57246 ; Hlac_1661 .
GeneIDi 7399612.
KEGGi hla:Hlac_1661.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi NLSERGP.

Enzyme and pathway databases

BioCyci HLAC416348:GIWW-1699-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome1 of Halorubrum lacusprofundi ATCC 49239."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N.
    , Anderson I., DasSarma S., Cavicchioli R., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34.

Entry informationi

Entry nameiNADK_HALLT
AccessioniPrimary (citable) accession number: B9LPF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3