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Protein

NAD kinase

Gene

nadK

Organism
Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Proton acceptorUniRule annotation
Binding sitei168 – 1681NADUniRule annotation
Binding sitei170 – 1701NADUniRule annotation
Binding sitei205 – 2051NAD; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 672NADUniRule annotation
Nucleotide bindingi138 – 1392NADUniRule annotation
Nucleotide bindingi181 – 1866NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciHLAC416348:GIWW-1699-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Hlac_1661
OrganismiHalorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Taxonomic identifieri416348 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHalorubrum
ProteomesiUP000000740 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 275275NAD kinasePRO_1000133574Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi416348.Hlac_1661.

Structurei

3D structure databases

ProteinModelPortaliB9LPF8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiIVAQRDN.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

B9LPF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVGIVARKG SERAVAVADE LRDAVAGAGA SVWLDAETAD ALGEPAAGRE
60 70 80 90 100
VDALADCDLA VAVGGDGTFL FVARNAGDTP IVGVNLGEVG FLNAVPPEAA
110 120 130 140 150
EEAVVSEVEA FDRGEMNVRE APRLAARTDE WTSVPAANEV VIQGARRGPG
160 170 180 190 200
AGIDYEVRVD GSRYAGGHAD GVLVATPTGS TAYNLSEGGP LVHPAVSGLV
210 220 230 240 250
VNEMVAEEGM PPIVVDADAT VTVAVEGVDE VVVASDGRNV TTLPAPTEVT
260 270
VERTTPPMRI AGPPSDFFAA LEKLS
Length:275
Mass (Da):28,022
Last modified:March 24, 2009 - v1
Checksum:i3D67FE31021935F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001365 Genomic DNA. Translation: ACM57246.1.
RefSeqiWP_015910384.1. NC_012029.1.
YP_002566316.1. NC_012029.1.

Genome annotation databases

EnsemblBacteriaiACM57246; ACM57246; Hlac_1661.
GeneIDi7399612.
KEGGihla:Hlac_1661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001365 Genomic DNA. Translation: ACM57246.1.
RefSeqiWP_015910384.1. NC_012029.1.
YP_002566316.1. NC_012029.1.

3D structure databases

ProteinModelPortaliB9LPF8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi416348.Hlac_1661.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM57246; ACM57246; Hlac_1661.
GeneIDi7399612.
KEGGihla:Hlac_1661.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiIVAQRDN.

Enzyme and pathway databases

BioCyciHLAC416348:GIWW-1699-MONOMER.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome1 of Halorubrum lacusprofundi ATCC 49239."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N.
    , Anderson I., DasSarma S., Cavicchioli R., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34.

Entry informationi

Entry nameiNADK_HALLT
AccessioniPrimary (citable) accession number: B9LPF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: July 22, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.