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B9LP84

- PYRF_HALLT

UniProt

B9LP84 - PYRF_HALLT

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931Proton donorUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciHLAC416348:GIWW-1621-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:Hlac_1586
    OrganismiHalorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
    Taxonomic identifieri416348 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalorubrum
    ProteomesiUP000000740: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Orotidine 5'-phosphate decarboxylasePRO_1000164749Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi416348.Hlac_1586.

    Structurei

    3D structure databases

    ProteinModelPortaliB9LP84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000245747.
    KOiK01591.
    OMAiCRTSNAG.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01215. OMPdecase_type2.
    InterProiIPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9LP84-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFFETLADR IEATDSVVSV GLDPDPNRLP EFLANADLPR WAFNRRIIDA    50
    THEHAACYKP NAAFYEDADG WRALEETIAY AHGKDVPVLL DAKRADIGNT 100
    TRQYAAALDR ADAITVNPYL GRDSLQPFLD REEKGVFVLC RTSNPGGSDL 150
    QDLELASGEP LYERVAALAD VWNGNDNVGL VVGATAPEEL AEVREIVPEI 200
    PFLVPGVGAQ GGDAEAAVEH GLADRPDAAV DVGLVNSSRG IIFAGEESSR 250
    PDDEATYFGA AGDAAKRLKK RLNQYR 276
    Length:276
    Mass (Da):29,838
    Last modified:March 24, 2009 - v1
    Checksum:iC8412DCC9224E76D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001365 Genomic DNA. Translation: ACM57172.1.
    RefSeqiYP_002566242.1. NC_012029.1.

    Genome annotation databases

    EnsemblBacteriaiACM57172; ACM57172; Hlac_1586.
    GeneIDi7399534.
    KEGGihla:Hlac_1586.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001365 Genomic DNA. Translation: ACM57172.1 .
    RefSeqi YP_002566242.1. NC_012029.1.

    3D structure databases

    ProteinModelPortali B9LP84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 416348.Hlac_1586.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM57172 ; ACM57172 ; Hlac_1586 .
    GeneIDi 7399534.
    KEGGi hla:Hlac_1586.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000245747.
    KOi K01591.
    OMAi CRTSNAG.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci HLAC416348:GIWW-1621-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01215. OMPdecase_type2.
    InterProi IPR013785. Aldolase_TIM.
    IPR018089. OMPdecase_AS.
    IPR011995. OMPdecase_type-2.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome1 of Halorubrum lacusprofundi ATCC 49239."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N.
      , Anderson I., DasSarma S., Cavicchioli R., Richardson P.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34.

    Entry informationi

    Entry nameiPYRF_HALLT
    AccessioniPrimary (citable) accession number: B9LP84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3