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B9LP66

- B9LP66_HALLT

UniProt

B9LP66 - B9LP66_HALLT

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Protein

Thymidine kinase

Gene
tdk, Hlac_1567
Organism
Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei92 – 921Proton acceptor By similarityUniRule annotation
Metal bindingi148 – 1481Zinc By similarityUniRule annotation
Metal bindingi151 – 1511Zinc By similarityUniRule annotation
Metal bindingi186 – 1861Zinc By similarityUniRule annotation
Metal bindingi189 – 1891Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATP By similarityUniRule annotation
Nucleotide bindingi91 – 944ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciHLAC416348:GIWW-1602-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Hlac_1567Imported
OrganismiHalorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)Imported
Taxonomic identifieri416348 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHalobacterialesHalobacteriaceaeHalorubrum
ProteomesiUP000000740: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi416348.Hlac_1567.

Structurei

3D structure databases

ProteinModelPortaliB9LP66.
SMRiB9LP66. Positions 1-194.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9LP66-1 [UniParc]FASTAAdd to Basket

« Hide

MHAITRSGWI EVISGSMFSG KTEELLRRLR RSEIAGQSVA VYKPAVDDRY    50
GETTIGSHNG RQWEATVVDN EGGGPLAILD DEPFPEVVAI DEANFFSDAL 100
VEVCNALADN GTRVIVSGTD QTFRGEPFEP LPELMATAEY VDKLQAICSQ 150
CGEPASRNQR LIEGEPAHVD DPTILVGAEE SYEARCRDCH VLRTGERSEA 200
DRAYLNGERV AENGSEKQEE PIDSGATDD 229
Length:229
Mass (Da):25,016
Last modified:March 24, 2009 - v1
Checksum:i771DFD21552F23C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001365 Genomic DNA. Translation: ACM57154.1.
RefSeqiWP_015910294.1. NC_012029.1.
YP_002566224.1. NC_012029.1.

Genome annotation databases

EnsemblBacteriaiACM57154; ACM57154; Hlac_1567.
GeneIDi7401500.
KEGGihla:Hlac_1567.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001365 Genomic DNA. Translation: ACM57154.1 .
RefSeqi WP_015910294.1. NC_012029.1.
YP_002566224.1. NC_012029.1.

3D structure databases

ProteinModelPortali B9LP66.
SMRi B9LP66. Positions 1-194.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 416348.Hlac_1567.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM57154 ; ACM57154 ; Hlac_1567 .
GeneIDi 7401500.
KEGGi hla:Hlac_1567.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.

Enzyme and pathway databases

BioCyci HLAC416348:GIWW-1602-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome1 of Halorubrum lacusprofundi ATCC 49239."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N.
    , Anderson I., DasSarma S., Cavicchioli R., Richardson P.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34.

Entry informationi

Entry nameiB9LP66_HALLT
AccessioniPrimary (citable) accession number: B9LP66
Entry historyi
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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