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B9LP48 (B9LP48_HALLT) Unreviewed, UniProtKB/TrEMBL

Last modified November 16, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Catalase-peroxidase HAMAP MF_01961
Short name=CP HAMAP MF_01961
EC=1.11.1.21 HAMAP MF_01961
Alternative name(s):
Peroxidase/catalase HAMAP MF_01961
Gene names
Name:katG HAMAP MF_01961
Ordered Locus Names:Hlac_1548
OrganismHalorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) [Complete proteome] [HAMAP]
Taxonomic identifier416348 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halorubrum

Protein attributes

Sequence length712 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity By similarity. HAMAP MF_01961

Catalytic activity

2 H2O2 = O2 + 2 H2O. HAMAP MF_01961 RuleBase RU003451

Donor + H2O2 = oxidized donor + 2 H2O. HAMAP MF_01961

Cofactor

Binds 1 heme B (iron-protoporphyrin IX) group per dimer By similarity. HAMAP MF_01961

Subunit structure

Homodimer or homotetramer By similarity. HAMAP MF_01961

Post-translational modification

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme By similarity. HAMAP MF_01961

Sequence similarities

Belongs to the peroxidase family. Peroxidase/catalase subfamily. HAMAP MF_01961 RuleBase RU003451

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site771Proton acceptor By similarity HAMAP MF_01961
Metal binding2421Iron (heme axial ligand) By similarity HAMAP MF_01961
Site731Transition state stabilizer By similarity HAMAP MF_01961

Amino acid modifications

Cross-link76 ↔ 201Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-227) By similarity HAMAP MF_01961
Cross-link201 ↔ 227Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-76) By similarity HAMAP MF_01961

Sequences

Sequence LengthMass (Da)Tools
B9LP48 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: D75DABCCE0431B7C

FASTA71279,575
        10         20         30         40         50         60 
MQGNTDWWPN QLNLDILDEN ARNAGPMDEE FDYAAAFEEL DLDAVKADIE DVMTTSQDWW 

        70         80         90        100        110        120 
PADYGTYGPL FIRMAWHSAG TYRTHDGRGG AAGGRQRLPP LNSWPDNVNL DKARRLLWPV 

       130        140        150        160        170        180 
KQKYGRKLSW ADLIVLTGNV ALESMGFETF GFAGGREDEF KPDDAVDWGP EDEWESSSAE 

       190        200        210        220        230        240 
RFDEGGSLDE ELGNTVMGLI YVNPEGPNGE PDLEGSAANI RDTFSHMAMN DKETVALIAG 

       250        260        270        280        290        300 
GHTFGKVHGA DSGDNLGPDP EDAPIDLQGL GWDNEHGEGK GPDTITSGIE GPWNATPTAW 

       310        320        330        340        350        360 
DLSYVNNLLS YDWEAERGPG GAWQWTTKND ELDDAAPGVQ DPSDKEDVMM LTTDVALKHD 

       370        380        390        400        410        420 
DDFRAVLEEF RDDPDEFQQS FAKAWYKLIH RDMGPPERFL GPEVPEETML WQDPLPDADY 

       430        440        450        460        470        480 
DIIGEAEIAE LEGLITEFDL SIADRVKTAW ASASTFRHSD KRGGANGARI RLEPQRSWEV 

       490        500        510        520        530        540 
NHPEELESVL ETYEEIQAEF NELRDDDTRV SLADLIVLGG TLAVEQAAAD AGHDVEVPFE 

       550        560        570        580        590        600 
PGRVDAAQDQ TDEESFEALE PDADGFRNYL GENLPHEPEH EMVDKAELLR LSVPEMAVLV 

       610        620        630        640        650        660 
GGMRVLDANY DNSDHGVFTN EPETLTNDFF VNLLDFDRDW EPVDEDEEVF ELRDHETGEV 

       670        680        690        700        710 
DWTATRFDLI FGSNSRLRAV SEVYGAADGE EKFVDDFADA WSKVMTLDRF DL

« Hide

References

[1]"Complete sequence of chromosome1 of Halorubrum lacusprofundi ATCC 49239."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. expand/collapse author list , Anderson I., DasSarma S., Cavicchioli R., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001365 Genomic DNA. Translation: ACM57136.1.
RefSeqYP_002566206.1. NC_012029.1.

3D structure databases

ProteinModelPortalB9LP48.
SMRB9LP48. Positions 2-712.
ModBaseSearch...

Protein-protein interaction databases

STRINGB9LP48.

Protein family/group databases

PeroxiBase7320. HlaCP01.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7401480.
GenomeReviewsGene locus Hlac_1548 in contig CP001365_GR.
KEGGhla:Hlac_1548.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAKRHAPSM.
ProtClustDBPRK15061.

Family and domain databases

HAMAPMF_01961. Catal_peroxid.
[Tree]
InterProIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
KOK03782.
PfamPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMSSF48113. Peroxidase_super. 2 hits.
TIGRFAMsTIGR00198. Cat_per_HPI. 1 hit.
PROSITEPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB9LP48_HALLT
AccessionPrimary (citable) accession number: B9LP48
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: November 16, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info