B9LN91 (B9LN91_HALLT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543
Ordered Locus Names:	Hlac_1237

Organism

Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34) [Complete proteome] [HAMAP]

Taxonomic identifier

416348 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Halobacteria › Halobacteriales › Halobacteriaceae › Halorubrum

Protein attributes

Sequence length	574 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543
Ligand	ATP-binding HAMAP MF_01543 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 EMBL ACM56829.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	82 – 89	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B9LN91 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 6210E019D1D74ED7	FASTA	574	59,213
	10 20 30 40 50 60 MVHADPAIDG ADTADAPESD LAVARAATPR PIEEVAADLG LAPDEIEPRG DGVAKLTQSA 70 80 90 100 110 120 VRSATASEPD GTTVLVTGMT PTPKGEGKTV TTVGLGQALA GLGESTAVAV REPSLGPVFG 130 140 150 160 170 180 IKGGAAGGGY SQVLPMESIN LHFTGDIHAL TAAHNLLSAA LDNHLHQGNE EGVDVRRVDW 190 200 210 220 230 240 PRALDVNDRA LRETVVGLGG PARGVPREDE FVITAASELM AVLGLAEDLS DLKTQIGRIV 250 260 270 280 290 300 LAEDADGDPV TPDDLGVTGA AAALLRDAFR PNLVQTIEGV PALVHGGPFA NIAHGTNTLV 310 320 330 340 350 360 ADRVGASLAD YLVTEAGFGA DLGAEKFAHI VAREGIVPDV AVVVATVRGA KRHGLEMWPA 370 380 390 400 410 420 DFDALAKTDP EAVRAGVDNV TRHVEIVESL GIPAVVGINV FPDDAESELA ALESTLTDAG 430 440 450 460 470 480 IPVARSTAYR DGGEGAMPLA ELVRERAGTG EFAPLYDLDA PLREKVETVA REVYGADGVE 490 500 510 520 530 540 YVDGADEDID RVEAWGYGDL PVCVSKTPYS FSDDASLTGV PEGWTLTVRE VSPSAGAGFV 550 560 570 VVKTADVMTM PGLPAEPAAE EIDVDADGNL SGLF

References

[1]

"Complete sequence of chromosome1 of Halorubrum lacusprofundi ATCC 49239." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ivanova N. , Anderson I., DasSarma S., Cavicchioli R., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001365 Genomic DNA. Translation: ACM56829.1.
RefSeq	YP_002565899.1. NC_012029.1.
3D structure databases
ProteinModelPortal	B9LN91.
SMR	B9LN91. Positions 20-572.
ModBase	Search...
Protein-protein interaction databases
STRING	B9LN91.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7399505.
GenomeReviews	Gene locus Hlac_1237 in contig CP001365_GR.
KEGG	hla:Hlac_1237.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MALTENA.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B9LN91_HALLT

Accession

Primary (citable) accession number: B9LN91

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	November 16, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)