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Protein

Nicotinamide-nucleotide adenylyltransferase

Gene

Hlac_1037

Organism
Halorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + nicotinamide ribonucleotide = diphosphate + NAD+.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinamide-nucleotide adenylyltransferase (Hlac_1037)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes NAD(+) from nicotinamide D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, NAD, Nucleotide-binding

Enzyme and pathway databases

BioCyciHLAC416348:GIWW-1061-MONOMER.
UniPathwayiUPA00253; UER00600.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinamide-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.1UniRule annotation)
Alternative name(s):
NAD(+) diphosphorylaseUniRule annotation
NAD(+) pyrophosphorylaseUniRule annotation
NMN adenylyltransferaseUniRule annotation
Gene namesi
Ordered Locus Names:Hlac_1037
OrganismiHalorubrum lacusprofundi (strain ATCC 49239 / DSM 5036 / JCM 8891 / ACAM 34)
Taxonomic identifieri416348 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaHalobacteriaHaloferacalesHaloferacaceaeHalorubrum
Proteomesi
  • UP000000740 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001253301 – 176Nicotinamide-nucleotide adenylyltransferaseAdd BLAST176

Interactioni

Protein-protein interaction databases

STRINGi416348.Hlac_1037.

Structurei

3D structure databases

ProteinModelPortaliB9LMP6.
SMRiB9LMP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal NMN adenylyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00972. Archaea.
COG1056. LUCA.
HOGENOMiHOG000108858.
KOiK00952.
OMAiNSVWVSH.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00243. NMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR006418. NMN_Atrans_arc.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01527. arch_NMN_Atrans. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

B9LMP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGFYIGRYQ PFHNGHRHMV EEIAAEVDEL VLGIGSAGDS HTTRNPFTAG
60 70 80 90 100
ERVMMVTKAV EKLDVTTYVV PIEDLDRNSV WVSHVQSMTP RFDIAYSNNP
110 120 130 140 150
LVVRLFEEAG VEARGSPMFR RDVLEGAELR ERMIHGRDWQ ALVPETVVDV
160 170
IEEIDGVERI RRIAETDANG TAPSDA
Length:176
Mass (Da):19,806
Last modified:March 24, 2009 - v1
Checksum:iE713B9EC399099B3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001365 Genomic DNA. Translation: ACM56634.1.
RefSeqiWP_015909781.1. NC_012029.1.

Genome annotation databases

EnsemblBacteriaiACM56634; ACM56634; Hlac_1037.
GeneIDi7400108.
KEGGihla:Hlac_1037.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001365 Genomic DNA. Translation: ACM56634.1.
RefSeqiWP_015909781.1. NC_012029.1.

3D structure databases

ProteinModelPortaliB9LMP6.
SMRiB9LMP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi416348.Hlac_1037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM56634; ACM56634; Hlac_1037.
GeneIDi7400108.
KEGGihla:Hlac_1037.

Phylogenomic databases

eggNOGiarCOG00972. Archaea.
COG1056. LUCA.
HOGENOMiHOG000108858.
KOiK00952.
OMAiNSVWVSH.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00600.
BioCyciHLAC416348:GIWW-1061-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00243. NMN_adenylyltr. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR006418. NMN_Atrans_arc.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01527. arch_NMN_Atrans. 1 hit.
TIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNADM_HALLT
AccessioniPrimary (citable) accession number: B9LMP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.