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B9LKW0 (FTHS_CHLSY) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Chy400_2847
OrganismChloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl) [Complete proteome] [HAMAP]
Taxonomic identifier480224 [NCBI]
Taxonomic lineageBacteriaChloroflexiChloroflexalesChloroflexaceaeChloroflexus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 572572Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000185250

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B9LKW0 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 25EFDFB2BF369EF9

FASTA57260,580
        10         20         30         40         50         60 
MKTSLQIAAE ARLEPIAAIA ERLGLPVRYL EPYGRYRGKI DLTFLDDYHD RPLGRYVLVS 

        70         80         90        100        110        120 
AITPTPLGEG KTTTAIGLAM ALNRIGKRAA VTLRQSSLGP VFGIKGGGAG GGYSQIVPLV 

       130        140        150        160        170        180 
ESILHLNGDI HAVSQAHNQL AALTDNSWYH GNPLDIDPDR IEIRRVVDVN DRFLRQVMIG 

       190        200        210        220        230        240 
LGGKQNGFPR QTGFDISVAS ELMAILAMVN GVGARAALRD LRSRIGRMVV AFRRDGTPIT 

       250        260        270        280        290        300 
AEDVRGAGAA TVLMREALKP NLMQTIENTP ALIHAGPFAN IAQGNSSILA DLIALRCADY 

       310        320        330        340        350        360 
VVTEAGFGVD IGAEKFFNLK CRASGLWPDV AVIVATIRAL KAHSGKYDIV AGKPLPPALL 

       370        380        390        400        410        420 
HENPDDVISG GANLRRQIEN LHQFKVPVIV ALNAYPEDTP AEIDAVAHIA TTAGAAGMAV 

       430        440        450        460        470        480 
SNVYAAGSAG GVDLARLVIE IAERPGPRPV QFLYPLEWSL ADKITTIAHR IYGAAAVTFS 

       490        500        510        520        530        540 
PTAAAQLAAL EDAGFGNLPI CMAKTHLSLS HDPALRGAPE GFTFPIREVR LSAGAGFILP 

       550        560        570 
IAGTTVTMPG LGAHPAAHQI DIDDEGNIVG LF 

« Hide

References

[1]"Complete sequence of Chloroflexus sp. Y-400-fl."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Kiss H., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Ovchinnikova G., Bryant D.A., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29364 / DSM 637 / Y-400-fl.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001364 Genomic DNA. Translation: ACM54235.1.
RefSeqYP_002570561.1. NC_012032.1.

3D structure databases

ProteinModelPortalB9LKW0.
SMRB9LKW0. Positions 5-570.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING480224.Chy400_2847.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM54235; ACM54235; Chy400_2847.
GeneID7404319.
KEGGchl:Chy400_2847.
PATRIC21425345. VBIChlSp61043_2951.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBCLSK983690.

Enzyme and pathway databases

BioCycCSP480224:GHIY-2891-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_CHLSY
AccessionPrimary (citable) accession number: B9LKW0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: April 16, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways