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B9LKW0

- FTHS_CHLSY

UniProt

B9LKW0 - FTHS_CHLSY

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSP480224:GHIY-2891-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Chy400_2847
    OrganismiChloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)
    Taxonomic identifieri480224 [NCBI]
    Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
    ProteomesiUP000007725: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 572572Formate--tetrahydrofolate ligasePRO_1000185250Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi480224.Chy400_2847.

    Structurei

    3D structure databases

    ProteinModelPortaliB9LKW0.
    SMRiB9LKW0. Positions 5-570.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9LKW0-1 [UniParc]FASTAAdd to Basket

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    MKTSLQIAAE ARLEPIAAIA ERLGLPVRYL EPYGRYRGKI DLTFLDDYHD    50
    RPLGRYVLVS AITPTPLGEG KTTTAIGLAM ALNRIGKRAA VTLRQSSLGP 100
    VFGIKGGGAG GGYSQIVPLV ESILHLNGDI HAVSQAHNQL AALTDNSWYH 150
    GNPLDIDPDR IEIRRVVDVN DRFLRQVMIG LGGKQNGFPR QTGFDISVAS 200
    ELMAILAMVN GVGARAALRD LRSRIGRMVV AFRRDGTPIT AEDVRGAGAA 250
    TVLMREALKP NLMQTIENTP ALIHAGPFAN IAQGNSSILA DLIALRCADY 300
    VVTEAGFGVD IGAEKFFNLK CRASGLWPDV AVIVATIRAL KAHSGKYDIV 350
    AGKPLPPALL HENPDDVISG GANLRRQIEN LHQFKVPVIV ALNAYPEDTP 400
    AEIDAVAHIA TTAGAAGMAV SNVYAAGSAG GVDLARLVIE IAERPGPRPV 450
    QFLYPLEWSL ADKITTIAHR IYGAAAVTFS PTAAAQLAAL EDAGFGNLPI 500
    CMAKTHLSLS HDPALRGAPE GFTFPIREVR LSAGAGFILP IAGTTVTMPG 550
    LGAHPAAHQI DIDDEGNIVG LF 572
    Length:572
    Mass (Da):60,580
    Last modified:March 24, 2009 - v1
    Checksum:i25EFDFB2BF369EF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001364 Genomic DNA. Translation: ACM54235.1.
    RefSeqiYP_002570561.1. NC_012032.1.

    Genome annotation databases

    EnsemblBacteriaiACM54235; ACM54235; Chy400_2847.
    GeneIDi7404319.
    KEGGichl:Chy400_2847.
    PATRICi21425345. VBIChlSp61043_2951.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001364 Genomic DNA. Translation: ACM54235.1 .
    RefSeqi YP_002570561.1. NC_012032.1.

    3D structure databases

    ProteinModelPortali B9LKW0.
    SMRi B9LKW0. Positions 5-570.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 480224.Chy400_2847.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM54235 ; ACM54235 ; Chy400_2847 .
    GeneIDi 7404319.
    KEGGi chl:Chy400_2847.
    PATRICi 21425345. VBIChlSp61043_2951.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CSP480224:GHIY-2891-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 29364 / DSM 637 / Y-400-fl.

    Entry informationi

    Entry nameiFTHS_CHLSY
    AccessioniPrimary (citable) accession number: B9LKW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3