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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Chy400_0038
OrganismiChloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)
Taxonomic identifieri480224 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001900161 – 310Methionyl-tRNA formyltransferaseAdd BLAST310

Structurei

3D structure databases

ProteinModelPortaliB9LFJ4
SMRiB9LFJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni109 – 112Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

B9LFJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILFLGSPS FAVHALEALV AAGHEIVGVV TQPDRPAGRD RRLTPPPVKI
60 70 80 90 100
AAMAHNLPVL QPETLRDPTV VETLSALQPE VGVVAAYGEI LRRAVLSIPP
110 120 130 140 150
LGYLNIHPSL LPLYRGPTPV AGAILAGETV TGVTIMLLDP SMDSGPILAQ
160 170 180 190 200
AVVDLPPTAR AGQLTDELFR IGADLLVQVL PRYARGEIEP RPQDHSRATV
210 220 230 240 250
TKMLKKEDGR IDWSLPAIVI ERMTRAYDPW PGAYTFWRGQ PLRIIKAAVA
260 270 280 290 300
SADGTNVPGT VIGRSGSGHP LVQTGSDALE LIEVQPASRR PMSGSAWLAG
310
VHADNIRLGE
Length:310
Mass (Da):33,137
Last modified:March 24, 2009 - v1
Checksum:iC238A6878775B27A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001364 Genomic DNA Translation: ACM51482.1
RefSeqiWP_012255944.1, NC_012032.1

Genome annotation databases

EnsemblBacteriaiACM51482; ACM51482; Chy400_0038
KEGGichl:Chy400_0038

Similar proteinsi

Entry informationi

Entry nameiFMT_CHLSY
AccessioniPrimary (citable) accession number: B9LFJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health