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B9LE47

- PROA_CHLSY

UniProt

B9LE47 - PROA_CHLSY

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Protein
Gamma-glutamyl phosphate reductase
Gene
proA, Chy400_1753
Organism
Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity.

Catalytic activityi

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. glutamate-5-semialdehyde dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-proline biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Proline biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCSP480224:GHIY-1773-MONOMER.
UniPathwayiUPA00098; UER00360.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-glutamyl phosphate reductase (EC:1.2.1.41)
Short name:
GPR
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name:
GSA dehydrogenase
Gene namesi
Name:proA
Ordered Locus Names:Chy400_1753
OrganismiChloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)
Taxonomic identifieri480224 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus
ProteomesiUP000007725: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Gamma-glutamyl phosphate reductaseUniRule annotation
PRO_1000193586Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi480224.Chy400_1753.

Structurei

3D structure databases

ProteinModelPortaliB9LE47.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0014.
HOGENOMiHOG000246356.
KOiK00147.
OMAiALTSYKW.
OrthoDBiEOG6FFSCX.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPiMF_00412. ProA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFiPIRSF000151. GPR. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00407. proA. 1 hit.
PROSITEiPS01223. PROA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B9LE47-1 [UniParc]FASTAAdd to Basket

« Hide

MVDLEAIGRR AKTAARALAK LSTEQKNAAL CAIADGLLAR QDKILAANAA    50
DVADAEKGGT PPAIVDRMLL TPARLAAIAG DCRQVASLPD PVGEIFDRRE 100
LPSGLRLYKR RVPIGVIGAI YEARPNVTVD IASLCLKAGN AVILRGGSDI 150
ARSVAATTEV IALALEQAGL PAFAVQSIID PDRELVRQLL RLDRYVDMII 200
PRGGAGLHRF CVENATVPVI VGGMGVSHIY VEPSADFARA VPVIVNAKVQ 250
RPGACNALDT LLVHRAAAST FLPLVAAALA QHGVELRCDL EALAILADAP 300
GHEAWNLKPA SPTDFGCEFL ALIVAIKIVG SIDEALDHIA LYGGHSEAIL 350
TGDPISAERF TREVDATAVF VNASTRFNDG GQFGLGAEVA ISTNRLHARG 400
PMGLQELTTY TWIGEGDYLV RA 422
Length:422
Mass (Da):44,515
Last modified:March 24, 2009 - v1
Checksum:i68BC84715CCE3378
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001364 Genomic DNA. Translation: ACM53163.1.
RefSeqiYP_002569489.1. NC_012032.1.

Genome annotation databases

EnsemblBacteriaiACM53163; ACM53163; Chy400_1753.
GeneIDi7405142.
KEGGichl:Chy400_1753.
PATRICi21423067. VBIChlSp61043_1833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001364 Genomic DNA. Translation: ACM53163.1 .
RefSeqi YP_002569489.1. NC_012032.1.

3D structure databases

ProteinModelPortali B9LE47.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 480224.Chy400_1753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACM53163 ; ACM53163 ; Chy400_1753 .
GeneIDi 7405142.
KEGGi chl:Chy400_1753.
PATRICi 21423067. VBIChlSp61043_1833.

Phylogenomic databases

eggNOGi COG0014.
HOGENOMi HOG000246356.
KOi K00147.
OMAi ALTSYKW.
OrthoDBi EOG6FFSCX.

Enzyme and pathway databases

UniPathwayi UPA00098 ; UER00360 .
BioCyci CSP480224:GHIY-1773-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPi MF_00412. ProA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000151. GPR. 1 hit.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00407. proA. 1 hit.
PROSITEi PS01223. PROA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 29364 / DSM 637 / Y-400-fl.

Entry informationi

Entry nameiPROA_CHLSY
AccessioniPrimary (citable) accession number: B9LE47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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