B9LDR9 (ARGB_CHLSY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	Chy400_3668

Organism

Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl) [Complete proteome] [HAMAP]

Taxonomic identifier

480224 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Chloroflexus

Protein attributes

Sequence length	254 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 254	254	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000118347
Regions
	Region	40 – 41	2	Substrate binding By similarity
Sites
	Binding site	62	1	Substrate By similarity
	Binding site	158	1	Substrate By similarity
	Site	8	1	Transition state stabilizer By similarity
	Site	217	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	B9LDR9 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 5CBEBB8369118AAF	FASTA	254	25,905
	10 20 30 40 50 60 MTTISVIKVS GHELDDPTFL GGLTAALRGF QQPLVLVHGG GKEISAAVER AGLQIEFVDG 70 80 90 100 110 120 LRVTSPAVMD IMQMVVCGTI NKRIVTALVN AGVKAIGLSG LDLGLLRCEP YRPAGRDLGR 130 140 150 160 170 180 VGEVTAVDGA ALLHLLALGW MPVIAPVALG ATDGLSYNVN ADMVAEAVAG ALAGAELVFV 190 200 210 220 230 240 SNVPGVLVDG RVVPALTPAA VEELIANGVI SGGMIPKVRA ALAALQRGAS SVRIVNLAGL 250 HDGGTRFTHG ELSE

References

[1]

"Complete sequence of Chloroflexus sp. Y-400-fl." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Kiss H., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. , Ovchinnikova G., Bryant D.A., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29364 / DSM 637 / Y-400-fl.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001364 Genomic DNA. Translation: ACM55035.1.
RefSeq	YP_002571361.1. NC_012032.1.
3D structure databases
ProteinModelPortal	B9LDR9.
ModBase	Search...
Protein-protein interaction databases
STRING	B9LDR9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7403855.
GenomeReviews	Gene locus Chy400_3668 in contig CP001364_GR.
KEGG	chl:Chy400_3668.
PATRIC	21427165. VBIChlSp61043_3853.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	CNINVEK.
ProtClustDB	CLSK975146.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_CHLSY

Accession

Primary (citable) accession number: B9LDR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program