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B9LD34 (GLPK_CHLSY) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glycerol kinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK
Gene names
Name:glpK
Ordered Locus Names:Chy400_3552
OrganismChloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl) [Complete proteome] [HAMAP]
Taxonomic identifier480224 [NCBI]
Taxonomic lineageBacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Chloroflexus

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186

Sequence similarities

Belongs to the FGGY kinase family.

Ontologies

Keywords
   Biological processGlycerol metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycerol-3-phosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

glycerol kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Glycerol kinase HAMAP MF_00186
PRO_1000124186

Regions

Nucleotide binding411 – 4155ATP By similarity

Sites

Binding site121Substrate By similarity
Binding site161ATP By similarity
Binding site821Substrate By similarity
Binding site1341Substrate By similarity
Binding site2441Substrate By similarity
Binding site2661ATP By similarity
Binding site3101ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
B9LD34 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: 5430FC5685D7B803

FASTA49854,325
        10         20         30         40         50         60 
MAKYAAAIDQ GTTSTRCMIF DHSGNVICYD QKEHEQIYPR PGWVEHSPDE IWERTQSVIR 

        70         80         90        100        110        120 
GALSKGGLSA SDIVAVGITN QRETTVVWNR KTGRPVYNAI VWQDTRTDQI CNELAADGGQ 

       130        140        150        160        170        180 
DRFRPKVGLP LATYFSGPKI RWILDNVPGA REAAEAGDVV FGNIDTFLTW WLTGGPNGGV 

       190        200        210        220        230        240 
HVTDVTNASR TMLMNLETLD WDDEILGIMG IPRQMLPKIV PSSMVYGTAT GELAGVPVAG 

       250        260        270        280        290        300 
ILGDQQAAMV GQTCFDVGEA KNTYGTGSFM LLNTGTKLVP SKSGLLTTVC YKFGDQPAVY 

       310        320        330        340        350        360 
ALEGSIAITG ALVQWLRDNL GLITSSAEVE ALANLVEDNG GIYFVPAFSG LFAPYWRSDA 

       370        380        390        400        410        420 
RGVIVGLTRY VNKGHLARAV LEATAYQTRE VLDAMEQDSG VKLTALKVDG GMVYNNTLMQ 

       430        440        450        460        470        480 
FQADILGVPV IRPKVAETTS LGAAYAAGLA VGFWSNTDEM RANWGVDHTW TPQMDEATRE 

       490 
RLYRGWKKAV TRTFDWVE

« Hide

References

[1]"Complete sequence of Chloroflexus sp. Y-400-fl."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Kiss H., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Ovchinnikova G., Bryant D.A., Richardson P.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 29364 / DSM 637 / Y-400-fl.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001364 Genomic DNA. Translation: ACM54923.1.
RefSeqYP_002571249.1. NC_012032.1.

3D structure databases

ProteinModelPortalB9LD34.
ModBaseSearch...

Protein-protein interaction databases

STRINGB9LD34.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7405034.
GenomeReviewsGene locus Chy400_3552 in contig CP001364_GR.
KEGGchl:Chy400_3552.
PATRIC21426917. VBIChlSp61043_3729.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAATYFSGT.
ProtClustDBCLSK973769.

Family and domain databases

HAMAPMF_00186. Glycerol_kin.
[Tree]
InterProIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
KOK00864.
PANTHERPTHR10196. FGGY_kin. 1 hit.
PTHR10196:SF9. Glycerol_kin. 1 hit.
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. Glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLPK_CHLSY
AccessionPrimary (citable) accession number: B9LD34
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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