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Protein

Acetaldehyde dehydrogenase

Gene

Chy400_1472

Organism
Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei128Acyl-thioester intermediateUniRule annotation1
Binding sitei278NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 16NADUniRule annotation4
Nucleotide bindingi159 – 167NADUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAromatic hydrocarbons catabolism
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]UniRule annotation
Gene namesi
Ordered Locus Names:Chy400_1472
OrganismiChloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)
Taxonomic identifieri480224 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003876481 – 305Acetaldehyde dehydrogenaseAdd BLAST305

Structurei

3D structure databases

ProteinModelPortaliB9LCM0.
SMRiB9LCM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000052149.
KOiK04073.
OMAiTSAYVHK.
OrthoDBiPOG091H09NP.

Family and domain databases

HAMAPiMF_01657. Ac_ald_DH_ac. 1 hit.
InterProiView protein in InterPro
IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
PfamiView protein in Pfam
PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiView protein in SMART
SM00859. Semialdhyde_dh. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

B9LCM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIDKVKVAI LGSGNIGTDL MYKLLKQPGR MELALVAGID PASEGLARAR
60 70 80 90 100
QIGIPTATDG IESILADPDI RIVFDATSAK AHVRHARLLR DHGRIAIDLT
110 120 130 140 150
PAARGPYVVP PVNLGEHLEA HNVNLITCGG QATIPLVYAV SRVTAVRYAE
160 170 180 190 200
MVSTVASRSA GPGTRQNIDE FTFTTARGLE AIGGAREAKA IIILNPAHPP
210 220 230 240 250
ILMRNTIYVV PEGDFDEETV RQSVAQMVAD VQQYVPGYRL KSLPVIEQRS
260 270 280 290 300
TPWGERPVII MLLEVEGAGD FLPTYAGNLD IMTAAARRVG ELFAAHLLSK

LEVTV
Length:305
Mass (Da):32,852
Last modified:March 24, 2009 - v1
Checksum:i84E757C1B25C747C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001364 Genomic DNA. Translation: ACM52890.1.
RefSeqiWP_012257234.1. NC_012032.1.

Genome annotation databases

EnsemblBacteriaiACM52890; ACM52890; Chy400_1472.
KEGGichl:Chy400_1472.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiACDH_CHLSY
AccessioniPrimary (citable) accession number: B9LCM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 24, 2009
Last modified: June 7, 2017
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families