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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of N7-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N7-methylguanine(46) in tRNA.UniRule annotation

Pathwayi: N(7)-methylguanine-tRNA biosynthesis

This protein is involved in the pathway N(7)-methylguanine-tRNA biosynthesis, which is part of tRNA modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway N(7)-methylguanine-tRNA biosynthesis and in tRNA modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57S-adenosyl-L-methionineUniRule annotation1
Binding sitei82S-adenosyl-L-methionineUniRule annotation1
Binding sitei109S-adenosyl-L-methionineUniRule annotation1
Binding sitei167SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00989

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
Name:trmBUniRule annotation
Ordered Locus Names:Chy400_3349
OrganismiChloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl)
Taxonomic identifieri480224 [NCBI]
Taxonomic lineageiBacteriaChloroflexiChloroflexiaChloroflexalesChloroflexineaeChloroflexaceaeChloroflexus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003879441 – 224tRNA (guanine-N(7)-)-methyltransferaseAdd BLAST224

Structurei

3D structure databases

ProteinModelPortaliB9LBT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000033410
KOiK03439
OMAiGHALEYC
OrthoDBiPOG091H015P

Family and domain databases

HAMAPiMF_01057 tRNA_methyltr_TrmB, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR003358 tRNA_(Gua-N-7)_MeTrfase_Trmb
PANTHERiPTHR23417 PTHR23417, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51625 SAM_MT_TRMB, 1 hit

Sequencei

Sequence statusi: Complete.

B9LBT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRGRYPARL YVTAPPPEIA ARYYRSWPAK ELYHTPEHFP PVSAEGLFGY
60 70 80 90 100
NAPLTLEFGC ATGEYLCALA AAQPSSCFVG IDIVAKPLYR AVERAVAGNL
110 120 130 140 150
SNILFIHADA RLIYQRIPTA ALHSIILHFP PPLLRNRQRN QLLVSPQLLE
160 170 180 190 200
CAARTLVPGG YLSFLTDHPA LFALMQELLP AFPALRATPA SVEELAVFES
210 220
HYHRRWAARG RTISGLRIER VMED
Length:224
Mass (Da):24,960
Last modified:March 24, 2009 - v1
Checksum:iA30622F44EFDBF20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001364 Genomic DNA Translation: ACM54726.1
RefSeqiWP_012258953.1, NC_012032.1

Genome annotation databases

EnsemblBacteriaiACM54726; ACM54726; Chy400_3349
KEGGichl:Chy400_3349

Similar proteinsi

Entry informationi

Entry nameiTRMB_CHLSY
AccessioniPrimary (citable) accession number: B9LBT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: March 24, 2009
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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