B9LB07 (B9LB07_CHLSY) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Adenylate kinase 2 HAMAP MF_00235
Short name=AK 2 HAMAP MF_00235
EC=2.7.4.3 HAMAP MF_00235

Alternative name(s):
ATP-AMP transphosphorylase 2 HAMAP MF_00235

Gene names

Name:	adk2 HAMAP MF_00235
Ordered Locus Names:	Chy400_3202

Organism

Chloroflexus aurantiacus (strain ATCC 29364 / DSM 637 / Y-400-fl) [Complete proteome] [HAMAP] EMBL ACM54580.1

Taxonomic identifier

480224 [NCBI]

Taxonomic lineage

Bacteria › Chloroflexi › Chloroflexales › Chloroflexaceae › Chloroflexus

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth By similarity. HAMAP MF_00235
Catalytic activity	ATP + AMP = 2 ADP. HAMAP MF_00235
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1. HAMAP MF_00235
Subunit structure	Monomer By similarity. HAMAP MF_00235
Subcellular location	Cytoplasm By similarity HAMAP MF_00235.
Domain	Consists of three domains, a large central CORE domain and two small peripheral domains, AMP binding and LID. The LID domain closes over the site of phosphoryl transfer upon ATP binding By similarity. HAMAP MF_00235
Sequence similarities	Belongs to the adenylate kinase family. HAMAP MF_00235

Ontologies

Keywords
Biological process	Nucleotide biosynthesis HAMAP MF_00235
Cellular component	Cytoplasm HAMAP MF_00235
Ligand	ATP-binding HAMAP MF_00235 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00235 EMBL ACM54580.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP adenylate kinase activity Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	10 – 18	9	ATP By similarity HAMAP MF_00235
	Nucleotide binding	34 – 62	29	AMP By similarity HAMAP MF_00235

Sequences

	Sequence		Length	Mass (Da)
	B9LB07 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 7904278A90A27A39	FASTA	216	23,775
	10 20 30 40 50 60 MTGRTILLIG PPGAGKTTIA GQLAQVTGMA VIATGQQLRA EIRAQSALGR YIEPLLEQGQ 70 80 90 100 110 120 LAPDSVMAEL MRNWLQRIPI DQDCLLDGYP RSVAQAHMLE TILADLGRRV DAVIVLTLDE 130 140 150 160 170 180 ATIVHRLSGR RICRRDDGQD ITVHIDDTAK IAQCLARGGT LVQREDDHPD VIRTRLRLYE 190 200 210 QETAPVLNYY TGRVPVHYVN ADQSPAAVVA LIRDII

References

[1]

"Complete sequence of Chloroflexus sp. Y-400-fl." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Kiss H., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N. , Ovchinnikova G., Bryant D.A., Richardson P. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 29364 / DSM 637 / Y-400-fl.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001364 Genomic DNA. Translation: ACM54580.1.
RefSeq	YP_002570906.1. NC_012032.1.
3D structure databases
ProteinModelPortal	B9LB07.
ModBase	Search...
Protein-protein interaction databases
STRING	B9LB07.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7404113.
GenomeReviews	Gene locus Chy400_3202 in contig CP001364_GR.
KEGG	chl:Chy400_3202.
PATRIC	21426182. VBIChlSp61043_3365.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EMQKYIL.
ProtClustDB	CLSK973426.
Family and domain databases
HAMAP	MF_00235. Adenylate_kinase_Adk. [Tree]
InterPro	IPR006259. Adenyl_kin_sub. IPR000850. Adenylate_kin. IPR003593. ATPase_AAA+_core. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01351. Adk. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B9LB07_CHLSY

Accession

Primary (citable) accession number: B9LB07

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)