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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciNPRO598659:G1GU9-1133-MONOMER
UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:NAMH_1145
OrganismiNautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)
Taxonomic identifieri598659 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNautilialesNautiliaceaeNautilia
Proteomesi
  • UP000000448 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003823511 – 420Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei259N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB9LA83

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi598659.NAMH_1145

Structurei

3D structure databases

ProteinModelPortaliB9LA83
SMRiB9LA83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

B9LA83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIFEEAKKY IVGGVNSPVR AFKSVGGEPP FIEKGEGAYI YDINGNKYLD
60 70 80 90 100
YIQSWGPLIF GHCDKDIEKA ICNAVSKGVS FGAPTTVEVE LAKEVLDLFP
110 120 130 140 150
HLDLIRFVNS GTEATMSAIR VARGVSGKDD IIKFEGCYHG HSDSLLVSAG
160 170 180 190 200
SGAATFGTPS SPGVPADFTK HTLLAKYNDI ESVKKCFENG NVGCVIIEPI
210 220 230 240 250
AGNMSLVPAE KEFLTELREL CTKNGAILIF DEVMSGFRAG LRGSYDVYGI
260 270 280 290 300
EADIVTFGKV IGGGMPVGAF AGKKVIMEQL SPEGPIYQAG TLSGNPVAMS
310 320 330 340 350
AGLAMLKKLK SNPELYKDLE SKAKKLMKGF EEISKENGID IQTNVVGSMF
360 370 380 390 400
GFFFNSKKPK NFDDVNESDT KRYAKFHSEM LKRGFYFAPS AYETGFICTV
410 420
MNDTDIDATL NAYKEIAPSL
Length:420
Mass (Da):45,461
Last modified:March 24, 2009 - v1
Checksum:i4C3E74E5C8991DE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001279 Genomic DNA Translation: ACM93074.1
RefSeqiWP_015902126.1, NC_012115.1

Genome annotation databases

EnsemblBacteriaiACM93074; ACM93074; NAMH_1145
KEGGinam:NAMH_1145

Similar proteinsi

Entry informationi

Entry nameiGSA_NAUPA
AccessioniPrimary (citable) accession number: B9LA83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 24, 2009
Last modified: June 20, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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