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B9LA83

- GSA_NAUPA

UniProt

B9LA83 - GSA_NAUPA

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (24 Mar 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciNPRO598659:GH7N-1141-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:NAMH_1145
    OrganismiNautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)
    Taxonomic identifieri598659 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNautilialesNautiliaceaeNautilia
    ProteomesiUP000000448: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 420420Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000382351Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei259 – 2591N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi598659.NAMH_1145.

    Structurei

    3D structure databases

    ProteinModelPortaliB9LA83.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiAIAGHAN.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B9LA83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGIFEEAKKY IVGGVNSPVR AFKSVGGEPP FIEKGEGAYI YDINGNKYLD    50
    YIQSWGPLIF GHCDKDIEKA ICNAVSKGVS FGAPTTVEVE LAKEVLDLFP 100
    HLDLIRFVNS GTEATMSAIR VARGVSGKDD IIKFEGCYHG HSDSLLVSAG 150
    SGAATFGTPS SPGVPADFTK HTLLAKYNDI ESVKKCFENG NVGCVIIEPI 200
    AGNMSLVPAE KEFLTELREL CTKNGAILIF DEVMSGFRAG LRGSYDVYGI 250
    EADIVTFGKV IGGGMPVGAF AGKKVIMEQL SPEGPIYQAG TLSGNPVAMS 300
    AGLAMLKKLK SNPELYKDLE SKAKKLMKGF EEISKENGID IQTNVVGSMF 350
    GFFFNSKKPK NFDDVNESDT KRYAKFHSEM LKRGFYFAPS AYETGFICTV 400
    MNDTDIDATL NAYKEIAPSL 420
    Length:420
    Mass (Da):45,461
    Last modified:March 24, 2009 - v1
    Checksum:i4C3E74E5C8991DE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001279 Genomic DNA. Translation: ACM93074.1.
    RefSeqiWP_015902126.1. NC_012115.1.
    YP_002607541.1. NC_012115.1.

    Genome annotation databases

    EnsemblBacteriaiACM93074; ACM93074; NAMH_1145.
    GeneIDi7505142.
    KEGGinam:NAMH_1145.
    PATRICi22677003. VBINauPro131435_1107.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001279 Genomic DNA. Translation: ACM93074.1 .
    RefSeqi WP_015902126.1. NC_012115.1.
    YP_002607541.1. NC_012115.1.

    3D structure databases

    ProteinModelPortali B9LA83.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 598659.NAMH_1145.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACM93074 ; ACM93074 ; NAMH_1145 .
    GeneIDi 7505142.
    KEGGi nam:NAMH_1145.
    PATRICi 22677003. VBINauPro131435_1107.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi AIAGHAN.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci NPRO598659:GH7N-1141-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola."
      Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C.
      PLoS Genet. 5:E1000362-E1000362(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-1463 / DSM 18972 / AmH.

    Entry informationi

    Entry nameiGSA_NAUPA
    AccessioniPrimary (citable) accession number: B9LA83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: March 24, 2009
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3