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Protein

D-alanine--D-alanine ligase

Gene

NAMH_0945

Organism
Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciNPRO598659:G1GU9-937-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:NAMH_0945Imported
OrganismiNautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)Imported
Taxonomic identifieri598659 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNautilialesNautiliaceaeNautilia
Proteomesi
  • UP000000448 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi598659.NAMH_0945

Structurei

3D structure databases

ProteinModelPortaliB9L9N9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 323ATP-graspInterPro annotationAdd BLAST188

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4105CPF Bacteria
COG1181 LUCA
HOGENOMiHOG000102494
KOiK01921
OMAiRCDFFVI
OrthoDBiPOG091H06GK

Family and domain databases

Gene3Di3.30.1490.20, 1 hit
InterProiView protein in InterPro
IPR011761 ATP-grasp
IPR013815 ATP_grasp_subdomain_1
IPR000291 D-Ala_lig_Van_CS
IPR005905 D_ala_D_ala
IPR011095 Dala_Dala_lig_C
IPR011127 Dala_Dala_lig_N
IPR016185 PreATP-grasp_dom_sf
PfamiView protein in Pfam
PF07478 Dala_Dala_lig_C, 1 hit
PF01820 Dala_Dala_lig_N, 1 hit
SUPFAMiSSF52440 SSF52440, 1 hit
TIGRFAMsiTIGR01205 D_ala_D_alaTIGR, 1 hit
PROSITEiView protein in PROSITE
PS50975 ATP_GRASP, 1 hit
PS00843 DALA_DALA_LIGASE_1, 1 hit
PS00844 DALA_DALA_LIGASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

B9L9N9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFALLFGGN SFEHEISIVS AITLKDKIKK HTLEFIYIDQ NRNMYLVDKQ
60 70 80 90 100
NMKSKYFASG EYKNSQKIEI TKGGFKYTKG LLKKDVFLNY DAVINLIHGK
110 120 130 140 150
DGEDGKLAGI LEFFNIKSIT PNVEASVISY NKVLTKAYAK EIGVNVIDYE
160 170 180 190 200
IITEPKSSFD FPIIIKPARL GSSIGVSVVK TQEEFDYAFD VAREFDDLII
210 220 230 240 250
AEPFIEGIEE YNLAGCLAGG EFMLSNIEKV EKSDFLDFEK KYMDFSRKNV
260 270 280 290 300
MLSDVDKDLT ERIKKTFKKI YNSTFKNAII RCDFFVKEGS VYLNEINPIP
310 320 330 340
GSMANYLFDD FDDVLEKLAK NIESEKEVKI DFEYINKIQM AKGK
Length:344
Mass (Da):39,345
Last modified:March 24, 2009 - v1
Checksum:iB70E1338D28E2242
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001279 Genomic DNA Translation: ACM93621.1
RefSeqiWP_015902673.1, NC_012115.1

Genome annotation databases

EnsemblBacteriaiACM93621; ACM93621; NAMH_0945
KEGGinam:NAMH_0945

Similar proteinsi

Entry informationi

Entry nameiB9L9N9_NAUPA
AccessioniPrimary (citable) accession number: B9L9N9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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