B9L8B8 (SYR_NAUPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	NAMH_0458

Organism

Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH) [Complete proteome] [HAMAP]

Taxonomic identifier

598659 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Nautiliales › Nautiliaceae › Nautilia

Protein attributes

Sequence length	532 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm By similarity HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 532	532	Arginine--tRNA ligase HAMAP MF_00123		PRO_1000198926
Regions
	Motif	111 – 121	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	B9L8B8 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: C8D972E21D9E8CDA	FASTA	532	61,093
	10 20 30 40 50 60 MKQKVAGKFK DHLGELPPLS KPKNKDFGHF AVPIFKYAKM NKQNPQEFAA ALCDALGNCE 70 80 90 100 110 120 EFEKVEAVSG FVNITLSDSF LNEFANKVLS EKENFAKGSG KERILLEYIS ANPTGPLHIG 130 140 150 160 170 180 HARGAVFGDA IARIGRHIGY DVVTEYYVND AGRQITLLGL SVYLAAREIL GLDVKWPEEY 190 200 210 220 230 240 YRGEYIKDLA AEAIKEFGED YFKAEIDAEN FNDDKLNMWA KDKMLNLIKE DIKALNVTPF 250 260 270 280 290 300 DNWVSEKELY KHWDEVRAIL EKNGALYEKD GKVWLKSSEY KDEKDRVVVR EDGRPTYLAG 310 320 330 340 350 360 DIIYHWDKFK RNYDRYINIW GADHHGYIAR VKAAIKFLGF DPEKLEILLS QMVKLLKGGE 370 380 390 400 410 420 PYKMSKRAGN FILVSDVVKD VGADALRFVF LTKKADTHLE FDVDELNRQD SSNPAYYINY 430 440 450 460 470 480 AHARIKSIFR NKEMNLEDTV NIQLKDLSKD EKDLVFLALQ FPYVLEEAFI NREPHRLTNY 490 500 510 520 530 LYELASEFHS FYNKNKVIGS EKEEVRLKIL AVVASIIKLG LSLLGIEAKE RM

References

[1]

"Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola." Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C. PLoS Genet. 5:E1000362-E1000362(2009) [PubMed: 19197347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1463 / DSM 18972 / AmH.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001279 Genomic DNA. Translation: ACM92690.1.
RefSeq	YP_002606876.1. NC_012115.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B9L8B8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7505514.
GenomeReviews	Gene locus NAMH_0458 in contig CP001279_GR.
KEGG	nam:NAMH_0458.
PATRIC	22675635. VBINauPro131435_0437.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ETIRGCL.
ProtClustDB	PRK01611.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_NAUPA

Accession

Primary (citable) accession number: B9L8B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program