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B9L8B8 (SYR_NAUPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:NAMH_0458
OrganismNautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH) [Complete proteome] [HAMAP]
Taxonomic identifier598659 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaNautilialesNautiliaceaeNautilia

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_1000198926

Regions

Motif111 – 12111"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
B9L8B8 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: C8D972E21D9E8CDA

FASTA53261,093
        10         20         30         40         50         60 
MKQKVAGKFK DHLGELPPLS KPKNKDFGHF AVPIFKYAKM NKQNPQEFAA ALCDALGNCE 

        70         80         90        100        110        120 
EFEKVEAVSG FVNITLSDSF LNEFANKVLS EKENFAKGSG KERILLEYIS ANPTGPLHIG 

       130        140        150        160        170        180 
HARGAVFGDA IARIGRHIGY DVVTEYYVND AGRQITLLGL SVYLAAREIL GLDVKWPEEY 

       190        200        210        220        230        240 
YRGEYIKDLA AEAIKEFGED YFKAEIDAEN FNDDKLNMWA KDKMLNLIKE DIKALNVTPF 

       250        260        270        280        290        300 
DNWVSEKELY KHWDEVRAIL EKNGALYEKD GKVWLKSSEY KDEKDRVVVR EDGRPTYLAG 

       310        320        330        340        350        360 
DIIYHWDKFK RNYDRYINIW GADHHGYIAR VKAAIKFLGF DPEKLEILLS QMVKLLKGGE 

       370        380        390        400        410        420 
PYKMSKRAGN FILVSDVVKD VGADALRFVF LTKKADTHLE FDVDELNRQD SSNPAYYINY 

       430        440        450        460        470        480 
AHARIKSIFR NKEMNLEDTV NIQLKDLSKD EKDLVFLALQ FPYVLEEAFI NREPHRLTNY 

       490        500        510        520        530 
LYELASEFHS FYNKNKVIGS EKEEVRLKIL AVVASIIKLG LSLLGIEAKE RM 

« Hide

References

[1]"Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola."
Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C.
PLoS Genet. 5:E1000362-E1000362(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1463 / DSM 18972 / AmH.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001279 Genomic DNA. Translation: ACM92690.1.
RefSeqYP_002606876.1. NC_012115.1.

3D structure databases

ProteinModelPortalB9L8B8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING598659.NAMH_0458.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM92690; ACM92690; NAMH_0458.
GeneID7505514.
KEGGnam:NAMH_0458.
PATRIC22675635. VBINauPro131435_0437.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247214.
KOK01887.
OMANPNGPLH.
OrthoDBEOG6JB13C.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycNPRO598659:GH7N-456-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_NAUPA
AccessionPrimary (citable) accession number: B9L8B8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: April 16, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries