B9L820 (B9L820_NAUPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase EMBL ACM92981.1
EC=2.4.1.182 EMBL ACM92981.1

Gene names

Name:	lpxB EMBL ACM92981.1
Ordered Locus Names:	NAMH_0355

Organism

Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH) [Complete proteome] [HAMAP]

Taxonomic identifier

598659 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Nautiliales › Nautiliaceae › Nautilia

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL ACM92981.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B9L820 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 118EAB3017907F99	FASTA	344	39,387
	10 20 30 40 50 60 MNKILVSALE PSANLHLKQV LNECKVKNEK CNIVGVFDKS LGEPVIDGNE FNVMGFLDVL 70 80 90 100 110 120 PKIKLAKKAI NELAELSKKC DKVLLIDAPS FNLRLAKKIK EVNPGVEIIY YILPKVWAWK 130 140 150 160 170 180 KGRIKDVNRY VDKKAYIFPF EREIWTDGIY VGNPLLDEIK TFRDDKLYGN IAFLPGSRKS 190 200 210 220 230 240 EIKNLMPVFR ELIKHLPGNK ILAVPEIYKD KLSEIYGDLS GFEIVYDAHE ALLKSDFAYI 250 260 270 280 290 300 CSGTATLEAA IIGTPFVLMY KAREIEYIIA KMFVKLNYVG LANIIFEREG LGEFHKEYLQ 310 320 330 340 DFDIEKLIND FKNSSLKEFQ KKSDKLKEIL KHGSAKNVFK LLKL

References

[1]

"Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola." Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C. PLoS Genet. 5:E1000362-E1000362(2009) [PubMed: 19197347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001279 Genomic DNA. Translation: ACM92981.1.
RefSeq	YP_002606778.1. NC_012115.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B9L820.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7504683.
GenomeReviews	Gene locus NAMH_0355 in contig CP001279_GR.
KEGG	nam:NAMH_0355.
PATRIC	22675425. VBINauPro131435_0337.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NANEKAA.
ProtClustDB	PRK14089.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B9L820_NAUPA

Accession

Primary (citable) accession number: B9L820

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)