Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B9L7I2 (UPPP_NAUPA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:NAMH_0152
OrganismNautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH) [Complete proteome] [HAMAP]
Taxonomic identifier598659 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaNautilialesNautiliaceaeNautilia

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 261261Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000148821

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane97 – 11721Helical; Potential
Transmembrane134 – 15421Helical; Potential
Transmembrane175 – 19521Helical; Potential
Transmembrane208 – 22821Helical; Potential
Transmembrane239 – 25921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B9L7I2 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: AA30918F17D73BA2

FASTA26128,954
        10         20         30         40         50         60 
MSIFDSIILG IVEGITEFLP ISSTAHMIIV STLLGLKQSV QNVAFEVIIQ LGATLAIVLI 

        70         80         90        100        110        120 
YLEKINFKEI NLWKKVLIAF MPLAVIGFLL RHQIKALFTI QTVAWMFIIG GIVFFIVEKI 

       130        140        150        160        170        180 
YSEEKVKIRD VEKVSLREAL IIGFFQVFAL IPGTSRSGAT IVGGMLSGLS RKTAADFSFL 

       190        200        210        220        230        240 
LAIPTMFAAS GYELLKNIDS FTNQNMTVLA VGFVVSFIAS YIAVKLFLKY VQKYTLNAFG 

       250        260 
VYRIIFGIIL LYLINQGIIT S 

« Hide

References

[1]"Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola."
Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C.
PLoS Genet. 5:E1000362-E1000362(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-1463 / DSM 18972 / AmH.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001279 Genomic DNA. Translation: ACM93005.1.
RefSeqYP_002606590.1. NC_012115.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING598659.NAMH_0152.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACM93005; ACM93005; NAMH_0152.
GeneID7505234.
KEGGnam:NAMH_0152.
PATRIC22675025. VBINauPro131435_0148.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAVIYFRNE.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycNPRO598659:GH7N-153-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_NAUPA
AccessionPrimary (citable) accession number: B9L7I2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: May 14, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families