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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciNPRO598659:GH7N-153-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:NAMH_0152
OrganismiNautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH)
Taxonomic identifieri598659 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNautilialesNautiliaceaeNautilia
ProteomesiUP000000448 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalUniRule annotationAdd
BLAST
Transmembranei43 – 6321HelicalUniRule annotationAdd
BLAST
Transmembranei70 – 9021HelicalUniRule annotationAdd
BLAST
Transmembranei97 – 11721HelicalUniRule annotationAdd
BLAST
Transmembranei134 – 15421HelicalUniRule annotationAdd
BLAST
Transmembranei175 – 19521HelicalUniRule annotationAdd
BLAST
Transmembranei208 – 22821HelicalUniRule annotationAdd
BLAST
Transmembranei239 – 25921HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 261261Undecaprenyl-diphosphatasePRO_1000148821Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi598659.NAMH_0152.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiAQCFALI.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

B9L7I2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIFDSIILG IVEGITEFLP ISSTAHMIIV STLLGLKQSV QNVAFEVIIQ
60 70 80 90 100
LGATLAIVLI YLEKINFKEI NLWKKVLIAF MPLAVIGFLL RHQIKALFTI
110 120 130 140 150
QTVAWMFIIG GIVFFIVEKI YSEEKVKIRD VEKVSLREAL IIGFFQVFAL
160 170 180 190 200
IPGTSRSGAT IVGGMLSGLS RKTAADFSFL LAIPTMFAAS GYELLKNIDS
210 220 230 240 250
FTNQNMTVLA VGFVVSFIAS YIAVKLFLKY VQKYTLNAFG VYRIIFGIIL
260
LYLINQGIIT S
Length:261
Mass (Da):28,954
Last modified:March 24, 2009 - v1
Checksum:iAA30918F17D73BA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001279 Genomic DNA. Translation: ACM93005.1.
RefSeqiWP_015902057.1. NC_012115.1.

Genome annotation databases

EnsemblBacteriaiACM93005; ACM93005; NAMH_0152.
KEGGinam:NAMH_0152.
PATRICi22675025. VBINauPro131435_0148.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001279 Genomic DNA. Translation: ACM93005.1.
RefSeqiWP_015902057.1. NC_012115.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi598659.NAMH_0152.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACM93005; ACM93005; NAMH_0152.
KEGGinam:NAMH_0152.
PATRICi22675025. VBINauPro131435_0148.

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiAQCFALI.
OrthoDBiEOG6QP13M.

Enzyme and pathway databases

BioCyciNPRO598659:GH7N-153-MONOMER.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola."
    Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C.
    PLoS Genet. 5:E1000362-E1000362(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1463 / DSM 18972 / AmH.

Entry informationi

Entry nameiUPPP_NAUPA
AccessioniPrimary (citable) accession number: B9L7I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 24, 2009
Last modified: July 22, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.