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B9L7E4 (B9L7E4_NAUPA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glutamate--tRNA ligase 1 HAMAP MF_00022
EC=6.1.1.17 HAMAP MF_00022
Alternative name(s):
Glutamyl-tRNA synthetase 1 HAMAP MF_00022
Gene names
Name:gltX EMBL ACM93575.1
Synonyms:gltX1 HAMAP MF_00022
Ordered Locus Names:NAMH_0116
OrganismNautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH) [Complete proteome] [HAMAP]
Taxonomic identifier598659 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Nautiliales › Nautiliaceae › Nautilia

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity. HAMAP MF_00022

Catalytic activity

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu). HAMAP MF_00022

Subunit structure

Monomer By similarity. HAMAP MF_00022

Subcellular location

Cytoplasm By similarity HAMAP MF_00022.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family. HAMAP MF_00022 RuleBase RU003489

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Motif8 – 1811"HIGH" region By similarity HAMAP MF_00022
Motif234 – 2385"KMSKS" region By similarity HAMAP MF_00022

Sites

Binding site2371ATP By similarity HAMAP MF_00022

Sequences

Sequence LengthMass (Da)Tools
B9L7E4 [UniParc].

Last modified March 24, 2009. Version 1.
Checksum: BBFEAD9C605FC2EE

FASTA46153,668
        10         20         30         40         50         60 
MVITRFAPSP TGYLHIGGLR TALFNWLWAK KNNGKFRLRI EDTDLSRNKQ EAVDAILEAF 

        70         80         90        100        110        120 
NWTGLHWDDE VVFQSERFDK YKEYVKELLD KGMAYKCYLT KEELETIREA RMKGEEPPID 

       130        140        150        160        170        180 
IRKYRDFKGE LDKPYVIRFK APLSGKVGFE DGVKGKAEID ASQVDDFVIA RSDGTPTYNF 

       190        200        210        220        230        240 
VVVIDDHEMG MTDIIRGDDH FTNTFKQVLV YKAFGWDVPK FYHVPMIHNE KGSKMSKRDG 

       250        260        270        280        290        300 
AVDVMEYKRE GYLPEALLNF LVRLGWSHGD QEIFSIDEMI KLFDPKDINK APSRYNKEKL 

       310        320        330        340        350        360 
DWLNQHYIKN SPNERIVKLL KEDFGVDIEG HDKKEILIDE LKDRVKTLKE MAEEIKKMLS 

       370        380        390        400        410        420 
TPAEYNEKAV KKFLKDEVIS NLREFLVFLN DKEPKTPVDW HDVMNEFLEL KGIKPKFLMP 

       430        440        450        460 
PLRIAMVGDT KGIDLAAMLS ILGKDEVKKR ISKLLANFEV F

« Hide

References

[1]"Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola."
Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C.
PLoS Genet. 5:E1000362-E1000362(2009) [PubMed: 19197347] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001279 Genomic DNA. Translation: ACM93575.1.
RefSeqYP_002606552.1. NC_012115.1.

3D structure databases

ProteinModelPortalB9L7E4.
ModBaseSearch...

Protein-protein interaction databases

STRINGB9L7E4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7505574.
GenomeReviewsGene locus NAMH_0116 in contig CP001279_GR.
KEGGnam:NAMH_0116.
PATRIC22674949. VBINauPro131435_0110.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAANFNDES.
ProtClustDBPRK01406.

Family and domain databases

HAMAPMF_00022_B. Glu_tRNA_synth_B.
[Tree]
InterProIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-synth_Ib_bac/mito.
IPR000924. Glu/Gln-tRNA-synth_Ib.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:1.10.1160.10. Glu/Gln-tRNA-synth_Ic_a-bdl. 1 hit.
G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
G3DSA:1.10.10.350. tRNA_synt_bd. 1 hit.
KOK01885.
PANTHERPTHR10119. Glu_tRNA-synt_1c. 1 hit.
PTHR10119:SF1. PTHR10119:SF1. 1 hit.
PfamPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSPR00987. TRNASYNTHGLU.
SUPFAMSSF48163. tRNA-synt_bind. 1 hit.
TIGRFAMsTIGR00464. GltX_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB9L7E4_NAUPA
AccessionPrimary (citable) accession number: B9L7E4
Entry history
Integrated into UniProtKB/TrEMBL: March 24, 2009
Last sequence update: March 24, 2009
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info