B9L6X5 (B9L6X5_NAUPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1 HAMAP MF_00223
EC=3.5.4.16 HAMAP MF_00223

Alternative name(s):
GTP cyclohydrolase I HAMAP MF_00223

Gene names

Name:	folE HAMAP MF_00223 EMBL ACM92258.1
Ordered Locus Names:	NAMH_1733

Organism

Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH) [Complete proteome] [HAMAP]

Taxonomic identifier

598659 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Nautiliales › Nautiliaceae › Nautilia

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223 SAAS SAAS001474
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223 SAAS SAAS001474
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family. HAMAP MF_00223

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_00223
Ligand	GTP-binding HAMAP MF_00223 Metal-binding HAMAP MF_00223 SAAS SAAS001474 Nucleotide-binding Zinc HAMAP MF_00223 SAAS SAAS001474
Molecular function	Hydrolase HAMAP MF_00223 SAAS SAAS001474 EMBL ACM92258.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	78	1	Zinc By similarity HAMAP MF_00223
	Metal binding	81	1	Zinc By similarity HAMAP MF_00223
	Metal binding	149	1	Zinc By similarity HAMAP MF_00223

Sequences

	Sequence		Length	Mass (Da)
	B9L6X5 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: D66B18A4B1C2E4DA	FASTA	192	22,033
	10 20 30 40 50 60 MSVDLEKLEL AAKMILEAIG EDVDRDGLVK TPRRVAKSFE YICSGYFKDP KEVLNDALFE 70 80 90 100 110 120 STNNEMVVVR NIEFYSMCEH HILPFFGRVH VAYIPDKKVV GLSKIPRMVN VFARRLQIQE 130 140 150 160 170 180 QLTEQIADAI MEVVQPKGVG VVIHARHMCM EMRGVETKHS YTSSSALRGI FLEEKTREEF 190 FNIINAPIQT HF

References

[1]

"Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola." Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C. PLoS Genet. 5:E1000362-E1000362(2009) [PubMed: 19197347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001279 Genomic DNA. Translation: ACM92258.1.
RefSeq	YP_002608113.1. NC_012115.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B9L6X5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7504040.
GenomeReviews	Gene locus NAMH_1733 in contig CP001279_GR.
KEGG	nam:NAMH_1733.
PATRIC	22678159. VBINauPro131435_1675.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	KQIATAM.
ProtClustDB	PRK09347.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B9L6X5_NAUPA

Accession

Primary (citable) accession number: B9L6X5

Entry history

Integrated into UniProtKB/TrEMBL:	March 24, 2009
Last sequence update:	March 24, 2009
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)