B9L6E6 (KHSE_NAUPA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	NAMH_1545

Organism

Nautilia profundicola (strain ATCC BAA-1463 / DSM 18972 / AmH) [Complete proteome] [HAMAP]

Taxonomic identifier

598659 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Nautiliales › Nautiliaceae › Nautilia

Protein attributes

Sequence length	293 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384
Subcellular location	Cytoplasm Potential HAMAP MF_00384.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 293	293	Homoserine kinase HAMAP MF_00384		PRO_1000134257
Regions
	Nucleotide binding	84 – 94	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B9L6E6 [UniParc]. Last modified March 24, 2009. Version 1. Checksum: 41324231A603B2A8	FASTA	293	33,160
	10 20 30 40 50 60 MVITVPATSA NLGPGFDTLG LALNLRNEIE IVKSDYTSIE IYGENAEYLR TLKRNYFVEI 70 80 90 100 110 120 FMDHYKNLTG KEDSFKFKFN NKIPLSRGLG SSSAVIIAAI TAAYEMAQVP YKKDRIINLA 130 140 150 160 170 180 LSYEPHPDNI TPAALGGFCV AKLRKNRVYF LKKFIPTYLR AVVVIPNRTI STQKSRNALK 190 200 210 220 230 240 AHYNLKDIVT NISSASMITA AFFSEKFEIL RNVVEDKIHQ ENRMKAVPEL FKVREIALRE 250 260 270 280 290 GALMSTLSGS GSTFFNLAYK DDAYSIYNVL RDNFKDFTIK ILQFDNVGVK VYN

References

[1]

"Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola." Campbell B.J., Smith J.L., Hanson T.E., Klotz M.G., Stein L.Y., Lee C.K., Wu D., Robinson J.M., Khouri H.M., Eisen J.A., Cary S.C. PLoS Genet. 5:E1000362-E1000362(2009) [PubMed: 19197347] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-1463 / DSM 18972 / AmH.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001279 Genomic DNA. Translation: ACM93184.1.
RefSeq	YP_002607934.1. NC_012115.1.
3D structure databases
ProteinModelPortal	B9L6E6.
ModBase	Search...
Protein-protein interaction databases
STRING	B9L6E6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7505596.
GenomeReviews	Gene locus NAMH_1545 in contig CP001279_GR.
KEGG	nam:NAMH_1545.
PATRIC	22677785. VBINauPro131435_1493.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	GSAHADN.
ProtClustDB	PRK01212.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_NAUPA

Accession

Primary (citable) accession number: B9L6E6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 24, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program